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Hypotensive effects of genistein: from chemistry to medicine

2017-04-25Journal article Restricted access
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dc.contributor.authorSureda, Antoni
dc.contributor.authorSanches Silva, Ana
dc.contributor.authorSánchez-Machado, Dalia Isabel
dc.contributor.authorLópez-Cervantes, Jaime
dc.contributor.authorDaglia, Maria
dc.contributor.authorNabavi, Seyed Fazel
dc.contributor.authorNabavi, Seyed Mohammad
dc.date.accessioned2018-03-22T17:52:17Z
dc.date.available2018-03-22T17:52:17Z
dc.date.issued2017-04-25
dc.description.abstractGenistein (4', 5, 7-trihydroxyisoflavone), a naturally occurring flavonoid characteristic of Leguminoseae plants, is a phyto-oestrogen exerting oestrogenic activity as both an agonist and an antagonist substance. A large body of evidence suggests that genistein possesses many physiological and pharmacological properties that make this molecule a potential agent for the prevention and treatment of a number of chronic diseases. Growing evidence suggests that genistein could act as a vasodilating, anti-thrombotic, and anti-atherosclerotic agent, exerting these effects through different mechanisms of action. This paper aims to review data from the literature assessing the beneficial effects of genistein on hypertension, one of the most important cardiovascular disease risk factors along with hyperglycemia and hyperlidipemia. In addition, we discuss the chemistry, main sources and bioavailability of genistein. Scientific findings support genistein's potential as a promising anti-hypertensive agent in different experimental models. However, clinical trials are very limited and more research will be required before genistein intake can be recommended as part of therapies targeting raised blood pressure.pt_PT
dc.description.sponsorshipA. Sureda was supported by the Spanish Ministry of Health, Social Services and Equality (CIBEROBN - CB12/03/30038). Transparency document Transparencypt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationChem Biol Interact. 2017 Apr 25;268:37-46. doi: 10.1016/j.cbi.2017.02.012. Epub 2017 Feb 24.pt_PT
dc.identifier.doi10.1016/j.cbi.2017.02.012pt_PT
dc.identifier.issn0009-2797
dc.identifier.urihttp://hdl.handle.net/10400.18/5442
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0009279717301990?via%3Dihubpt_PT
dc.subjectAnimalspt_PT
dc.subjectAntihypertensive Agentspt_PT
dc.subjectGenisteinpt_PT
dc.subjectHumanspt_PT
dc.subjectHypertensionpt_PT
dc.subjectSegurança Alimentarpt_PT
dc.titleHypotensive effects of genistein: from chemistry to medicinept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage46pt_PT
oaire.citation.startPage37pt_PT
oaire.citation.titleChemico-Biological Interactionspt_PT
oaire.citation.volume268pt_PT
rcaap.rightsembargoedAccesspt_PT
rcaap.typearticlept_PT

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