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Exploring BPA alternatives - Environmental levels and toxicity review

2024-05-23Journal article Open access
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datacite.subject.fosCiências Naturais::Ciências Biológicas
dc.contributor.authorAdamovsky, Ondrej
dc.contributor.authorGroh, Ksenia J.
dc.contributor.authorBiałk-Bielińska, Anna
dc.contributor.authorEscher, Beate I.
dc.contributor.authorBeaudouin, R.
dc.contributor.authorMora Lagares, Liadys
dc.contributor.authorTollefsen, Knut Erik
dc.contributor.authorFenske, Martina
dc.contributor.authorMulkiewicz, Ewa
dc.contributor.authorCreusot, Nicolas
dc.contributor.authorSosnowska, Anita
dc.contributor.authorLoureiro, Susana
dc.contributor.authorBeyer, Jonny
dc.contributor.authorRepetto, Guillermo
dc.contributor.authorŠtern, Alja
dc.contributor.authorLopes, Isabel
dc.contributor.authorMonteiro, Marta
dc.contributor.authorZikova-Kloas, Andrea
dc.contributor.authorEleršek, Tina
dc.contributor.authorVračko, Marjan
dc.contributor.authorZdybel, Szymon
dc.contributor.authorPuzyn, Tomasz
dc.contributor.authorKoczur, Weronika
dc.contributor.authorEbsen Morthorst, Jane
dc.contributor.authorHolbech, Henrik
dc.contributor.authorCarlsson, Gunnar
dc.contributor.authorÖrn, Stefan
dc.contributor.authorHerrero, Óscar
dc.contributor.authorSiddique, Ayesha
dc.contributor.authorLiess, Matthias
dc.contributor.authorBraun, Georg
dc.contributor.authorSrebny, Vanessa
dc.contributor.authorŽegura, Bojana
dc.contributor.authorHinfray, Nathalie
dc.contributor.authorBrion, François
dc.contributor.authorKnapen, Dries
dc.contributor.authorVandeputte, Ellen
dc.contributor.authorStinckens, Evelyn
dc.contributor.authorVergauwen, Lucia
dc.contributor.authorBehrendt, Lars
dc.contributor.authorSilva, Maria João
dc.contributor.authorBlaha, Ludek
dc.contributor.authorKyriakopoulou, Katerina
dc.date.accessioned2025-02-25T13:14:46Z
dc.date.available2025-02-25T13:14:46Z
dc.date.issued2024-05-23
dc.description.abstractBisphenol A alternatives are manufactured as potentially less harmful substitutes of bisphenol A (BPA) that offer similar functionality. These alternatives are already in the market, entering the environment and thus raising ecological concerns. However, it can be expected that levels of BPA alternatives will dominate in the future, they are limited information on their environmental safety. The EU PARC project highlights BPA alternatives as priority chemicals and consolidates information on BPA alternatives, with a focus on environmental relevance and on the identification of the research gaps. The review highlighted aspects and future perspectives. In brief, an extension of environmental monitoring is crucial, extending it to cover BPA alternatives to track their levels and facilitate the timely implementation of mitigation measures. The biological activity has been studied for BPA alternatives, but in a non-systematic way and prioritized a limited number of chemicals. For several BPA alternatives, the data has already provided substantial evidence regarding their potential harm to the environment. We stress the importance of conducting more comprehensive assessments that go beyond the traditional reproductive studies and focus on overlooked relevant endpoints. Future research should also consider mixture effects, realistic environmental concentrations, and the long-term consequences on biota and ecosystems.por
dc.description.sponsorshipThis work was carried out in the framework of the European Partnership for the Assessment of Risks from Chemicals (PARC) and has received funding from the European Union’s Horizon Europe research and innovation programme under Grant Agreement No 101057014. This work was also supported from the European Union’s Horizon 2020 research and innovation program under grant agreement No 857560. Ondrej Adamovsky and Ludek Blaha thank the RECETOX Research Infrastructure (No LM2023069) financed by the Ministry of Education, Youth and Sports, for supportive background. Dr. Adamovsky thanks also The Czech Science Foundation (GACR), project 23-13617L, for support in plastic and plastic additives research. Alja Štern, Bojana Žegura and Tina Eleršek thank the ARIS program P1-0245 for supportive background. Susana Loureiro, Isabel Lopes and Marta S Monteiro thank the Foundation for Science and Technology and Ministry of Science, Technology and Higher Education (FCT/MCTES) for the financial support to CESAM (UIDP/50017/2020+UIDB/50017/2020+LA/P/0094/2020). Knut Erik Tollefsen and Jonny Beyer acknowledge the contribution from the Research Council of Norway projects 223268, 315969 and 342628. Dries Knapen, Lucia Vergauwen, Evelyn Stinckens and Ellen Vandeputte thank the University of Antwerp Research Fund (project 44602 and GOA project FFB180348/36572) and FPS Health, Food Chain Safety and Environment, DG Environment, in the framework of the National Action Plan on Endocrine Disruptors (NAPED, DGEM/DPPC/MJE/23079) for co-funding the work. Martina Fenske thanks the Federal Ministry for the Environment, Nature Conservation, Nuclear Safety and Consumer Protection (BMUV) for financial support (Action programme "Water management" of BfG and BMUV, Action 111.
dc.identifier.citationEnviron Int. 2024 Jul:189:108728. doi: 10.1016/j.envint.2024.108728. Epub 2024 May 23. Review
dc.identifier.doi10.1016/j.envint.2024.108728
dc.identifier.issn0160-4120
dc.identifier.pmid38850672
dc.identifier.urihttp://hdl.handle.net/10400.18/10384
dc.language.isoeng
dc.peerreviewedyes
dc.publisherElsevier
dc.relationEuropean Partnership for the Assessment of Risks from Chemicals (PARC)
dc.relationCETOCOEN Excellence
dc.relationCentre for Environmental and Marine Studies
dc.relationCentre for Environmental and Marine Studies
dc.relationCentre for Environmental and Marine Studies
dc.relation.hasversionhttps://www.sciencedirect.com/science/article/pii/S0160412024003143?via%3Dihub
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectBPA Alternatives
dc.subjectBiological Activity
dc.subjectIn silico
dc.subjectInvertebrates
dc.subjectVertebrates
dc.subjectGenotoxicidade Ambiental
dc.titleExploring BPA alternatives - Environmental levels and toxicity reviewpor
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleEuropean Partnership for the Assessment of Risks from Chemicals (PARC)
oaire.awardTitleCETOCOEN Excellence
oaire.awardTitleCentre for Environmental and Marine Studies
oaire.awardTitleCentre for Environmental and Marine Studies
oaire.awardTitleCentre for Environmental and Marine Studies
oaire.awardURIhttp://hdl.handle.net/10400.18/10383
oaire.awardURIinfo:eu-repo/grantAgreement/EC/H2020/857560/EU
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F50017%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F50017%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0094%2F2020/PT
oaire.citation.startPage108728
oaire.citation.titleEnvironment International
oaire.citation.volume189
oaire.fundingStreamHorizon Europe Guarantee
oaire.fundingStreamH2020
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameSilva
person.givenNameMaria João
person.identifier.orcid0000-0001-8821-0747
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameEuropean Commission
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
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