Publication
Loss of the Y chromosome in male patients with haematological disorders
| dc.contributor.author | Geraldes, Maria | |
| dc.contributor.author | Ambrósio, Ana | |
| dc.contributor.author | Almeida, Rita | |
| dc.contributor.author | Furtado, José | |
| dc.contributor.author | Correia, Hildeberto | |
| dc.date.accessioned | 2011-09-14T10:47:08Z | |
| dc.date.available | 2011-09-14T10:47:08Z | |
| dc.date.issued | 2011-07 | |
| dc.description.abstract | The clinical association between loss of the Y (L0Y) chromosome and haematological disorders has been continuously debated because both phenomena can be age-related. In order to understand the relationship between the L0Y chromosome and the different haematological diseases, we retrospectively analysed cytogenetic results of 1,241 male patients from 1995 to 2010. Seventyeight patients (6.3%) showed L0Y. Of the 78 patients without Y chromosome, 15 (19.2%) had B cell lymphomas (B lymphomas), 12 (15.4%) had myelodysplastic syndromes (MDS), 10 (12.8%) had chronic myelogeneous leukaemia (CML), 10 (12.8%) had acute myeloid leukaemia (AML), 8 (10.3%) had myeloproliferative neoplasms (MN), 6 (7.7%) had chronic lymphocytic leukaemia (CLL), 5 (6.4%) had multiple myeloma (MM), 5 (6.4%) had other mature B cell neoplasms (BN), 3 (3.8%) had MDS/MN, 3 (3.8%) had other mature T cell neoplasms (TN), and 1 (1.3%) had acute lymphoblastic leukaemia (ALL). We did not observe the L0Y chromosome in the 15 patients (1.2% of all patients studied) with Hodgkin’s disease. These percentages can be different if we consider only the pathology in which the L0Y was found: 4.1% of all patients with MN, 5.7% of all patients with MDS, 9.3% in the patients with AML, 12.5% in patients with ALL, 5.8% in patients with CLL, 5.8% in B lymphoma patients, 8.2% in the CML patients, 4.5% in MM patients, 9.1% in BN patients, 9.1% in MDS/MN patients and 15.8% in TN patients. Twenty-five patients (32.1%) had the L0Y associated with other cytogenetic anomalies. There are few reports of L0Y associated with haematological disorders since this has been considered mainly an age-related event. Therefore, the tendency of L0Y diseases to be associated that seems apparent in our data indicates that careful consideration should be taken when evaluating male patients with L0Y. | por |
| dc.identifier.citation | Chromosome Res. 2011;19(Suppl 1):S167 | por |
| dc.identifier.issn | 0967-3849 | |
| dc.identifier.uri | http://hdl.handle.net/10400.18/161 | |
| dc.language.iso | eng | por |
| dc.peerreviewed | yes | por |
| dc.publisher | SpringerLink | por |
| dc.relation.ispartofseries | 6.P63 | |
| dc.relation.publisherversion | http://www.springerlink.com/content/6453372m5087667h/fulltext.pdf | por |
| dc.subject | Haematological diseases | por |
| dc.subject | Loss of the Y chromosome | por |
| dc.subject | Doenças Genéticas | por |
| dc.title | Loss of the Y chromosome in male patients with haematological disorders | por |
| dc.type | conference object | |
| dspace.entity.type | Publication | |
| oaire.citation.conferencePlace | Porto, Portugal | por |
| oaire.citation.startPage | S167 | por |
| oaire.citation.title | Chromosome Research - 8th Cytogenetic European Conference 2011 | por |
| rcaap.rights | openAccess | por |
| rcaap.type | conferenceObject | por |