Regulation of glucose transporters by protein kinases in cancer cells

Henriques, Andreia; Matos, Paulo; Jordan, Peter

Publication

Regulation of glucose transporters by protein kinases in cancer cells

2017-09Conference object

dc.contributor.author	Henriques, Andreia
dc.contributor.author	Matos, Paulo
dc.contributor.author	Jordan, Peter
dc.date.accessioned	2018-03-13T12:49:58Z
dc.date.available	2018-03-13T12:49:58Z
dc.date.issued	2017-09
dc.description	ESMO 2017 - 42nd European Society of Medical Oncology Congress 2017, 8-12 September 2017, Madrid, Spain
dc.description.abstract	Background: Cancer cells require increased glucose supply to sustain proliferation. One mechanism involves increased expression of glucose transporter (GLUT) genes. But insulin has revealed that protein phosphorylation is another key mechanism in glucose uptake regulation: insulin binding to responsive cells triggers a signalling cascade with phosphorylation of TBC1D4, a negative regulator of endosomal GLUT trafficking, so that more transporters are inserted into the plasma membrane. Previous work from the host lab has identified the family of WNK protein kinases and shown that WNK1 can also phosphorylate TBC1D4 and promote GLUT translocation to the cell surface. Our objective is to understand the contribution of WNK1 to glucose uptake in colorectal cancer cells. Our objective is to understand the contribution of WNK1 to glucose uptake in colorectal cancer cells.	pt_PT
dc.description.sponsorship	Fundação para a Ciência e Tecnologia BioISI - Biosystems and Integrative Sciences Institute	pt_PT
dc.description.version	N/A	pt_PT
dc.identifier.citation	Ann Oncol. 2017 Sept;28(Suppl 5):50-52. doi:10.1093/annonc/mdx361.036.
dc.identifier.doi	10.1093/annonc/mdx361.036
dc.identifier.issn	0923-7534
dc.identifier.uri	http://hdl.handle.net/10400.18/5393
dc.language.iso	eng	pt_PT
dc.peerreviewed	no	pt_PT
dc.publisher	Oxford University Press/European Society for Medical Oncology
dc.relation.publisherversion	http://oncologypro.esmo.org/Meeting-Resources/ESMO-2017-Congress/Regulation-of-glucose-transporters-by-protein-kinases-in-cancer-cells	pt_PT
dc.relation.publisherversion	https://academic.oup.com/annonc/article/28/suppl_5/mdx361.036/4108277?searchresult=1
dc.subject	WNK Protein Kinases	pt_PT
dc.subject	Colorectal Cancer	pt_PT
dc.subject	Transporte de Glucose	pt_PT
dc.subject	Vias de Transdução de Sinal e Patologias Associadas	pt_PT
dc.subject	Cancro Coloretal	pt_PT
dc.title	Regulation of glucose transporters by protein kinases in cancer cells	pt_PT
dc.type	conference object
dspace.entity.type	Publication
oaire.citation.title	Annals of Oncology
rcaap.rights	openAccess	pt_PT
rcaap.type	conferenceObject	pt_PT