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DNA damage in circulating leukocytes measured with the comet assay may predict the risk of death

2021-08-18Journal article Open access
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dc.contributor.authorBonassi, Stefano
dc.contributor.authorCeppi, Marcello
dc.contributor.authorMøller, Peter
dc.contributor.authorAzqueta, Amaya
dc.contributor.authorMilić, Mirta
dc.contributor.authorNeri, Monica
dc.contributor.authorBrunborg, Gunnar
dc.contributor.authorGodschalk, Roger
dc.contributor.authorKoppen, Gudrun
dc.contributor.authorLangie, Sabine A.S.
dc.contributor.authorTeixeira, João Paulo
dc.contributor.authorBruzzone, Marco
dc.contributor.authorDa Silva, Juliana
dc.contributor.authorBenedetti, Danieli
dc.contributor.authorCavallo, Delia
dc.contributor.authorUrsini, Cinzia Lucia
dc.contributor.authorGiovannelli, Lisa
dc.contributor.authorMoretti, Silvia
dc.contributor.authorRiso, Patrizia
dc.contributor.authorDel Bo’, Cristian
dc.contributor.authorRusso, Patrizia
dc.contributor.authorDobrzyńska, Malgorzata
dc.contributor.authorGoroshinskaya, Irina A.
dc.contributor.authorSurikova, Ekaterina I.
dc.contributor.authorStaruchova, Marta
dc.contributor.authorBarančokova, Magdalena
dc.contributor.authorVolkovova, Katarina
dc.contributor.authorKažimirova, Alena
dc.contributor.authorSmolkova, Bozena
dc.contributor.authorLaffon, Blanca
dc.contributor.authorValdiglesias, Vanessa
dc.contributor.authorPastor, Susana
dc.contributor.authorMarcos, Ricard
dc.contributor.authorHernández, Alba
dc.contributor.authorGajski, Goran
dc.contributor.authorSpremo-Potparević, Biljana
dc.contributor.authorŽivković, Lada
dc.contributor.authorBoutet-Robinet, Elisa
dc.contributor.authorPerdry, Hervé
dc.contributor.authorLebailly, Pierre
dc.contributor.authorPerez, Carlos L.
dc.contributor.authorBasaran, Nursen
dc.contributor.authorNemeth, Zsuzsanna
dc.contributor.authorSafar, Anna
dc.contributor.authorDusinska, Maria
dc.contributor.authorCollins, Andrew
dc.contributor.authorAnderson, Diana
dc.contributor.authorAndrade, Vanessa
dc.contributor.authorPereira, Cristiana Costa
dc.contributor.authorCosta, Solange
dc.contributor.authorGutzkow, Kristine B.
dc.contributor.authorLadeira, Carina
dc.contributor.authorMoretti, Massimo
dc.contributor.authorCosta, Carla
dc.contributor.authorOrlow, Irene
dc.contributor.authorRojas, Emilio
dc.contributor.authorPourrut, Bertrand
dc.contributor.authorKruszewski, Marcin
dc.contributor.authorKnasmueller, Siegfried
dc.contributor.authorShaposhnikov, Sergey
dc.contributor.authorŽegura, Bojana
dc.contributor.authorStopper, Helga
dc.date.accessioned2022-07-11T16:20:37Z
dc.date.available2022-07-11T16:20:37Z
dc.date.issued2021-08-18
dc.descriptionCollaborators hCOMET project: Diana Anderson, Vanessa Andrade, Cristiana Costa Pereira, Solange Costa, Kristine B Gutzkow, Carina Ladeira, Massimo Moretti, Carla Costa, Irene Orlow, Emilio Rojas, Bertrand Pourrut, Marcin Kruszewski, Siegfried Knasmueller, Sergey Shaposhnikov, Bojana Žegura, Helga Stopper.pt_PT
dc.descriptionErratum in - Author Correction. Sci Rep. 2021 Sep 20;11(1):19043. doi: 10.1038/s41598-021-98620-6.pt_PT
dc.description.abstractThe comet assay or single cell gel electrophoresis, is the most common method used to measure strand breaks and a variety of other DNA lesions in human populations. To estimate the risk of overall mortality, mortality by cause, and cancer incidence associated to DNA damage, a cohort of 2,403 healthy individuals (25,978 person-years) screened in 16 laboratories using the comet assay between 1996 and 2016 was followed-up. Kaplan-Meier analysis indicated a worse overall survival in the medium and high tertile of DNA damage (p < 0.001). The effect of DNA damage on survival was modelled according to Cox proportional hazard regression model. The adjusted hazard ratio (HR) was 1.42 (1.06-1.90) for overall mortality, and 1.94 (1.04-3.59) for diseases of the circulatory system in subjects with the highest tertile of DNA damage. The findings of this study provide epidemiological evidence encouraging the implementation of the comet assay in preventive strategies for non-communicable diseases.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSci Rep. 2021 Aug 18;11(1):16793. doi: 10.1038/s41598-021-95976-7pt_PT
dc.identifier.doi10.1038/s41598-021-95976-7pt_PT
dc.identifier.issn2045-2322
dc.identifier.urihttp://hdl.handle.net/10400.18/8225
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherNature Researchpt_PT
dc.relation.publisherversionhttps://www.nature.com/articles/s41598-021-95976-7pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectCell-Free Nucleic Acidspt_PT
dc.subjectComet Assaypt_PT
dc.subjectDNA Damagept_PT
dc.subjectLeukocytespt_PT
dc.subjectNeoplasmspt_PT
dc.subjectGenotoxicidade Ambientalpt_PT
dc.titleDNA damage in circulating leukocytes measured with the comet assay may predict the risk of deathpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue1pt_PT
oaire.citation.startPage16793pt_PT
oaire.citation.titleScientific Reportspt_PT
oaire.citation.volume11pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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