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Risk assessment of combined occupational exposure to hexavalent chromium, nickel, and PAHs: a literature-based approach

2020-11-18Conference object Restricted access
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dc.contributor.authorTavares, Ana Maria
dc.contributor.authorViegas, Susana
dc.contributor.authorLouro, Henriqueta
dc.contributor.authorSilva, Maria João
dc.date.accessioned2021-03-13T14:49:01Z
dc.date.available2021-03-13T14:49:01Z
dc.date.issued2020-11-18
dc.description.abstractOccupational exposure is usually characterized by a complex mixture of chemicals, originating from different raw materials and transformation processes. Co-exposure to hexavalent chromium (Cr(VI)), nickel (Ni) and polycyclic aromatic hydrocarbons (PAHs) can occur in some workplaces. These substances display well-known genotoxic and carcinogenic effects, especially in the respiratory tract, sharing similar modes of action. However, reference values for occupational exposure only account for individual components exposure and not for a potential mixture effect. In the scope of HBM4EU Initiative, we performed a mixtures risk assessment (MRA) based on literature from occupational studies conducted in the European Union that contain human biomonitoring (HBM) data on Cr(VI), Ni and/or PAHs. After HBM data extraction, Hazard Quotient (HQ) and Hazard Index (HI) were calculated for binary and tertiary mixtures. Exposure was considered of concern if HI>1. Twenty-four articles were selected, most (n=18, 75%) presenting Cr(VI) and Ni exposure biomarkers. Among these, HI>1 was obtained for all studies on welding activities, in which chromium was the main driver of toxicity with HQ>1 in most measurements. Only two studies in waste incineration setting reported exposure to the three substances, and again all HI>1. Noteworthy, for some of the analysed studies, although exposure levels were below the reference values, still the mixture was considered of concern (HI>1). Our findings show the limitations of applying occupational exposure reference values defined on a single substance basis to workplaces, highlighting the relevance of MRA as a more realistic approach to provide more suitable risk management measures in occupational settings.pt_PT
dc.description.sponsorshipHBM4EU Grant agreement ID: 733032pt_PT
dc.description.versionN/Apt_PT
dc.identifier.urihttp://hdl.handle.net/10400.18/7441
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationEuropean Human Biomonitoring Initiative
dc.subjectEnvironmental Genotoxicitypt_PT
dc.subjectHuman Biomonitoringpt_PT
dc.subjectMixtures Risk Assessmentpt_PT
dc.subjectHexavalent Chromiumpt_PT
dc.subjectPAHspt_PT
dc.subjectNickelpt_PT
dc.subjectGenotoxicidade Ambientalpt_PT
dc.titleRisk assessment of combined occupational exposure to hexavalent chromium, nickel, and PAHs: a literature-based approachpt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.awardTitleEuropean Human Biomonitoring Initiative
oaire.awardURIinfo:eu-repo/grantAgreement/EC/H2020/733032/EU
oaire.citation.conferencePlaceLisboa, Portugal (online)pt_PT
oaire.citation.title3rd HBM-PT Workshop on Human BioMonitoring in Portugal, 18 november 2020pt_PT
oaire.fundingStreamH2020
person.familyNameLouro
person.familyNameSilva
person.givenNameHenriqueta
person.givenNameMaria João
person.identifier157627
person.identifier.ciencia-id721D-2BB1-7DB1
person.identifier.orcid0000-0001-9744-7332
person.identifier.orcid0000-0001-8821-0747
person.identifier.scopus-author-id6507971479
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.nameEuropean Commission
rcaap.rightsrestrictedAccesspt_PT
rcaap.typeconferenceObjectpt_PT
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relation.isAuthorOfPublicationb2a2c2f7-2740-4657-8e50-7ff7fb468a96
relation.isAuthorOfPublication.latestForDiscoveryb2a2c2f7-2740-4657-8e50-7ff7fb468a96
relation.isProjectOfPublication6815dc2d-ef7e-4535-8dd3-5193c8bffba5
relation.isProjectOfPublication.latestForDiscovery6815dc2d-ef7e-4535-8dd3-5193c8bffba5

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