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Evidence of Endocrine Disruption and Oxidative Stress in Mytilus galloprovincialis Exposed to 17α-Ethinylestradiol

2026-04-30Artigo científico Acesso aberto
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dc.contributor.authorCopeto, Sandra
dc.contributor.authorFerreira, Inês João
dc.contributor.authorMansilha, Catarina
dc.contributor.authorMelo, Armindo
dc.contributor.authorMotta, Carla
dc.contributor.authorSilva, Marco
dc.contributor.authorDiniz, Mário
dc.date.accessioned2026-10-01T12:22:07Z
dc.date.available2026-10-01T12:22:07Z
dc.date.issued2026-04-30
dc.description(This article belongs to the Special Issue Marine Bivalves Toxicology)
dc.description.abstractThe presence of endocrine-disrupting compounds (EDCs) in aquatic environments has raised significant concerns, particularly regarding their impact on marine biota. Among these compounds, 17α-ethinylestradiol (EE2), a synthetic estrogen widely used in oral contraceptives, is highly persistent and biologically active at very low concentrations. This study evaluated the effects of EE2 exposure on oxidative stress responses and endocrine disruption in Mytilus galloprovincialis, exposed for 28 days to three EE2 concentrations (10, 30, and 300 ng·L−1). Biomarkers of oxidative stress, including the enzymatic activities of superoxide dismutase (SOD), catalase (CAT), and glutathione-S-transferase (GST), as well as Lipid Peroxidation (MDA levels), total ubiquitin (UBI) and the endocrine disruption marker, vitellogenin-like protein (VTG) were assessed. Results showed significant increase in GST and a decrease in CAT activities followed by an elevation at 300 ng·L−1, slightly higher than control values. Overall, results suggest an enhanced oxidative challenge. No significant changes were detected in MDA and UBI levels. VTG-like protein levels increased according to the EE2 concentrations tested, suggesting an effect on the mussel’s endocrine system. These results show the activation of detoxification and antioxidant defense mechanisms in exposed mussels as a response to mitigate oxidative stress damage. Furthermore, it highlights the importance of using biomarkers in pollution monitoring studies and environmental risk assessment.eng
dc.description.sponsorshipThis work was supported by FCT—Fundação para a Ciência e Tecnologia, I.P., in the scope of the project UID/04378/2025 (DOI identifier 10.54499/UID/04378/2025), and UID/PRR/04378/2025 (DOI identifier 10.54499/UID/PRR/04378/2025), of the Research Unit on Applied Molecular Bio-sciences—UCIBIO and the project LA/P/0140/2020 (DOI identifier 10.54499/LA/P/0140/2020) of the Associate Laboratory Institute for Health and Bioeconomy—i4HB; and by the Associate La-boratory for Green Chemistry, LAQV, which is financed by national funds from FCT/MCTES (UID/QUI/50006/2019).
dc.identifier.citationJ Mar Sci Eng. 2026 Apr 30; 14:829. doi: 10.3390/jmse14090829
dc.identifier.doi10.3390/jmse14090829
dc.identifier.eid2-s2.0-105038470955
dc.identifier.issn2077-1312
dc.identifier.urihttp://hdl.handle.net/10400.18/11363
dc.language.isoeng
dc.peerreviewedyes
dc.publisherMDPI
dc.relationUID/04378/2025
dc.relationUID/PRR/04378/2025
dc.relationLA/P/0140/2020
dc.relationUID/QUI/50006/2019
dc.relation.hasversionhttps://www.mdpi.com/2077-1312/14/9/829
dc.relation.ispartofJournal of Marine Science and Engineering
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject17α-ethinylestradiol
dc.subjectMytilus galloprovincialis
dc.subjectOxidative Stress
dc.subjectAntioxidant Enzymes
dc.subjectVitellogenin
dc.subjectEndocrine Disruption
dc.subjectToxicologia
dc.subjectSegurança Alimentar
dc.subjectAvaliação do Risco
dc.subjectÁgua e Solo
dc.titleEvidence of Endocrine Disruption and Oxidative Stress in Mytilus galloprovincialis Exposed to 17α-Ethinylestradioleng
dc.typejournal article
dcterms.referenceshttps://www.mdpi.com/article/10.3390/jmse14090829/s1
dspace.entity.typePublication
oaire.citation.issue9
oaire.citation.startPage829
oaire.citation.titleJournal of Marine Science and Engineering
oaire.citation.volume14
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85

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