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Assessment of indoor air exposure at residential homes: Inhalation dose and lung deposition of PM10, PM2.5 and ultrafine particles among newborn children and their mothers

2020-05-15Journal article Restricted access
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dc.contributor.authorMadureira, Joana
dc.contributor.authorSlezakova, Klara
dc.contributor.authorSilva, Ana Inês
dc.contributor.authorLage, Bruna
dc.contributor.authorMendes, Ana
dc.contributor.authorAguiar, Lívia
dc.contributor.authorPereira, Maria Carmo
dc.contributor.authorTeixeira, João Paulo
dc.contributor.authorCosta, Carla
dc.date.accessioned2021-03-04T12:26:16Z
dc.date.available2021-03-04T12:26:16Z
dc.date.issued2020-05-15
dc.description.abstractAccurate assessment of particulate matter (PM) dose and respiratory deposition is essential to better understand the risks of exposure to PM and, consequently, to develop the respective risk-control strategies. In homes, this is especially relevant in regards to ultrafine particles (UFP; <0.1 μm) which origin in these environments is mostly due to indoor sources. Thus, this study aimed to estimate inhalation doses for different PM mass/number size fractions (i.e., PM10, PM2.5 and UFP) in indoor air of residential homes and to quantify the deposition (total, regional and lobar) in human respiratory tract for both newborn children and mothers. Indoor real-time measurements of PM10, PM2.5 and UFP were conducted in 65 residential homes situated in Oporto metropolitan area (Portugal). Inhalation doses were estimated based on the physical characteristics of individual subjects and their activity patterns. The multi-path particle dosimetry model was used to quantify age-specific depositions in human respiratory tract. The results showed that 3-month old infants exhibited 4-fold higher inhalation doses than their mothers. PM10 were primarily deposited in the head region (87%), while PM2.5 and UFP depositions mainly occurred in the pulmonary area (39% and 43%, respectively). Subject age affected the pulmonary region and the total lung deposition; higher deposition being observed among the newborns. Similarly, lower lobes (left lobe: 37% and right lobe: 30%) received higher PM deposition than upper and middle lobes; right lobes lung are prone to be more susceptible to respiratory problems, since asymmetric deposition was observed. Considering that PM-related diseases occur at specific sites of respiratory system, quantification of site-specific particle deposition should be predicted in order to better evidence the respective health outcomes resulting from inhaled PM.pt_PT
dc.description.abstractHighlights: Inhalation dose and deposition of PM10, PM2.5, and UFP estimated in child and adults; Newborns (3 months) exhibited 4-fold higher inhalation doses than their mothers; PM10 deposited in head region, PM2.5 and UFP depositions occurred in pulmonary area; Lower lobes received higher PM deposition than upper and middle lobes; Right lobes lung are prone to be more susceptible to respiratory problems.pt_PT
dc.description.sponsorshipThis work was supported by FCT and FAPESP (FAPESP/19914/2014) and by base funding UIDB/00511/2020 of the Laboratory for Process Engineering, Environment, Biotechnology and Energy – LEPABE – funded by national funds through the FCT/MCTES (PIDDAC). Joana Madureira, Carla Costa and Ana Inês Silva are supported by FCT (SFRH/BPD/115112/2016, SFRH/BPD/96196/2013 and SFRH/BD/145101/2019 grants, respectively).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSci Total Environ. 2020 May 15;717:137293. doi: 10.1016/j.scitotenv.2020.137293. Epub 2020 Feb 18.pt_PT
dc.identifier.doi10.1016/j.scitotenv.2020.137293pt_PT
dc.identifier.issn0048-9697
dc.identifier.urihttp://hdl.handle.net/10400.18/7310
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationLaboratory for Process Engineering, Environment, Biotechnology and Energy
dc.relationEarly life exposure to atmospheric air pollutants and potential DNA damage: Consequences on development and childhood outcomes APPEAL
dc.relationImpact of transplacental exposure to tobacco smoke in the DNA of newborn. Evaluation of genetic damage and epigenetic changes. Evolution throughout childhood.
dc.relationEffects of in utero exposure to environmental contaminants: an epigenetic approach
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/abs/pii/S0048969720308032?via%3Dihubpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectAir Pollutantspt_PT
dc.subjectEnvironmental Monitoringpt_PT
dc.subjectFemalept_PT
dc.subjectHumanspt_PT
dc.subjectInfant, Newbornpt_PT
dc.subjectInhalation Exposurept_PT
dc.subjectMotherspt_PT
dc.subjectParticle Sizept_PT
dc.subjectParticulate Matterpt_PT
dc.subjectPortugalpt_PT
dc.subjectAir Pollution, Indoorpt_PT
dc.subjectAr e Saúde Ocupacionalpt_PT
dc.titleAssessment of indoor air exposure at residential homes: Inhalation dose and lung deposition of PM10, PM2.5 and ultrafine particles among newborn children and their motherspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleLaboratory for Process Engineering, Environment, Biotechnology and Energy
oaire.awardTitleEarly life exposure to atmospheric air pollutants and potential DNA damage: Consequences on development and childhood outcomes APPEAL
oaire.awardTitleImpact of transplacental exposure to tobacco smoke in the DNA of newborn. Evaluation of genetic damage and epigenetic changes. Evolution throughout childhood.
oaire.awardTitleEffects of in utero exposure to environmental contaminants: an epigenetic approach
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00511%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBPD%2F115112%2F2016/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBPD%2F96196%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POR_NORTE/SFRH%2FBD%2F145101%2F2019/PT
oaire.citation.startPage137293pt_PT
oaire.citation.titleScience of The Total Environmentpt_PT
oaire.citation.volume717pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamPOR_NORTE
project.funder.identifierhttp://doi.org/10.13039/501100001871
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project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.embargofctAcesso de acordo com política editorial da revista.pt_PT
rcaap.rightsembargoedAccesspt_PT
rcaap.typearticlept_PT
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