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Invasive pulmonary aspergillosis treatment duration in haematology patients in Europe: An EFISG, IDWP‐EBMT, EORTC‐IDG and SEIFEM survey

2020-05Journal article Restricted access
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dc.contributor.authorLanternier, Fanny
dc.contributor.authorSeidel, Danila
dc.contributor.authorPagano, Livio
dc.contributor.authorStyczynski, Jan
dc.contributor.authorMikulska, Malgorzata
dc.contributor.authorPulcini, Celine
dc.contributor.authorMaertens, Johan
dc.contributor.authorMunoz, Patricia
dc.contributor.authorGarcia‐Vidal, Carol
dc.contributor.authorRijnders, Bart
dc.contributor.authorArendrup, Maiken Cavling
dc.contributor.authorSabino, Raquel
dc.contributor.authorVerissimo, Cristina
dc.contributor.authorGaustad, Peter
dc.contributor.authorKlimko, Nikolay
dc.contributor.authorArikan‐Akdagli, Sevtap
dc.contributor.authorArsic, Valentina
dc.contributor.authorBarac, Aleksandra
dc.contributor.authorSkiada, Anna
dc.contributor.authorKlingspor, Lena
dc.contributor.authorHerbrecht, Raoul
dc.contributor.authorDonnelly, Peter
dc.contributor.authorCornely, Oliver A.
dc.contributor.authorLass‐Flörl, Cornelia
dc.contributor.authorLortholary, Olivier
dc.date.accessioned2021-03-09T15:53:33Z
dc.date.available2021-03-09T15:53:33Z
dc.date.issued2020-05
dc.description.abstractInvasive pulmonary aspergillosis (IPA) optimal duration of antifungal treatment is not known. In a joint effort, four international scientific societies/groups performed a survey to capture current practices in European haematology centres regarding management of IPA. We conducted a cross-sectional internet-based questionnaire survey in 2017 to assess practices in sixteen European countries concerning IPA management in haematology patients including tools to evaluate treatment response, duration and discontinuation. The following four groups/societies were involved in the project: European Society of Clinical Microbiology and Infectious Diseases (ESCMID) Fungal Infection Study Group (EFISG), Infectious Diseases Working Party-European Society for Blood and Bone Marrow Transplantation (IDWP-EBMT), European Organisation for Research and Treatment-Infectious Disease group (EORTC-IDG) and Sorveglianza Epidemiologica Infezioni nelle Emopatie (SEIFEM). A total of 112 physicians from 14/16 countries answered the survey. Galactomannan antigen was available in serum and bronchoalveolar lavage in most centres (106/112 [95%] and 97/112 [87%], respectively), quantitative Aspergillus PCR in 27/112 (24%) centres, β-D-glucan in 24/112 (21%) and positron emission tomography in 50/112 (45%). Treatment duration differed between haematological malignancies, with a median duration of 6 weeks [IQR 3-12] for patients with AML, 11 [4-12] for patients with allogenic stem cell transplantation and GvHD and 6 [3-12] for patients with lymphoproliferative disease. Treatment duration significantly differed according to country. Essential IPA biomarkers are not available in all European countries, and treatment duration is highly variable according to country. It will be important to provide guidelines to help with IPA treatment cessation with algorithms according to biomarker availability.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMycoses. 2020 May;63(5):420-429. doi: 10.1111/myc.13056. Epub 2020 Mar 4.pt_PT
dc.identifier.doi10.1111/myc.13056pt_PT
dc.identifier.issn0933-7407
dc.identifier.urihttp://hdl.handle.net/10400.18/7374
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherWiley/ Deutschsprachige Mykologische Gesellschaftpt_PT
dc.relation.publisherversionhttps://onlinelibrary.wiley.com/doi/abs/10.1111/myc.13056pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectAntifungal Agentspt_PT
dc.subjectAntigens, Fungalpt_PT
dc.subjectAspergilluspt_PT
dc.subjectBiomarkerspt_PT
dc.subjectBronchoalveolar Lavage Fluidpt_PT
dc.subjectCross-Sectional Studiespt_PT
dc.subjectDisease Managementpt_PT
dc.subjectDuration of Therapypt_PT
dc.subjectEuropept_PT
dc.subjectHematologic Neoplasmspt_PT
dc.subjectHumanspt_PT
dc.subjectInternationalitypt_PT
dc.subjectInvasive Pulmonary Aspergillosispt_PT
dc.subjectMannanspt_PT
dc.subjectPositron-Emission Tomographypt_PT
dc.subjectSurveys and Questionnairespt_PT
dc.subjectEuropept_PT
dc.subjectInfecções Sistémicas e Zoonosespt_PT
dc.titleInvasive pulmonary aspergillosis treatment duration in haematology patients in Europe: An EFISG, IDWP‐EBMT, EORTC‐IDG and SEIFEM surveypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage429pt_PT
oaire.citation.issue5pt_PT
oaire.citation.startPage420pt_PT
oaire.citation.titleMycosespt_PT
oaire.citation.volume63pt_PT
rcaap.embargofctAcesso de acordo com política editorial da revista.pt_PT
rcaap.rightsembargoedAccesspt_PT
rcaap.typearticlept_PT

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