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Hazard characterization of Alternaria toxins to identify data gaps and improve risk assessment for human health

2023-12-26Journal article Open access
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dc.contributor.authorLouro, Henriqueta
dc.contributor.authorVettorazzi, Ariane
dc.contributor.authorLópez de Cerain, Adela
dc.contributor.authorSpyropoulou, Anastasia
dc.contributor.authorSolhaug, Anita
dc.contributor.authorStraumfors, Anne
dc.contributor.authorBehr, Anne-Cathrin
dc.contributor.authorMertens, Birgit
dc.contributor.authorŽegura, Bojana
dc.contributor.authorFæste, Christiane Kruse
dc.contributor.authorNdiaye, Dieynaba
dc.contributor.authorSpilioti, Eliana
dc.contributor.authorVarga, Elisabeth
dc.contributor.authorDubreil, Estelle
dc.contributor.authorBorsos, Eszter
dc.contributor.authorCrudo, Francesco
dc.contributor.authorEriksen, Gunnar Sundstøl
dc.contributor.authorSnapkow, Igor
dc.contributor.authorHenri, Jérôme
dc.contributor.authorSanders, Julie
dc.contributor.authorMachera, Kyriaki
dc.contributor.authorGaté, Laurent
dc.contributor.authorLe Hegarat, Ludovic
dc.contributor.authorNovak, Matjaž
dc.contributor.authorSmith, Nicola M.
dc.contributor.authorKrapf, Solveig
dc.contributor.authorHager, Sonja
dc.contributor.authorFessard, Valérie
dc.contributor.authorKohl, Yvonne
dc.contributor.authorSilva, Maria João
dc.contributor.authorDirven, Hubert
dc.contributor.authorDietrich, Jessica
dc.contributor.authorMarko, Doris
dc.date.accessioned2024-01-03T13:56:50Z
dc.date.available2024-01-03T13:56:50Z
dc.date.issued2023-12-26
dc.description.abstractFungi of the genus Alternaria are ubiquitous plant pathogens and saprophytes which are able to grow under varying temperature and moisture conditions as well as on a large range of substrates. A spectrum of structurally diverse secondary metabolites with toxic potential has been identified, but occurrence and relative proportion of the different metabolites in complex mixtures depend on strain, substrate, and growth conditions. This review compiles the available knowledge on hazard identification and characterization of Alternaria toxins. Alternariol (AOH), its monomethylether AME and the perylene quinones altertoxin I (ATX-I), ATX-II, ATX-III, alterperylenol (ALP), and stemphyltoxin III (STTX-III) showed in vitro genotoxic and mutagenic properties. Of all identified Alternaria toxins, the epoxide-bearing analogs ATX-II, ATX-III, and STTX-III show the highest cytotoxic, genotoxic, and mutagenic potential in vitro. Under hormone-sensitive conditions, AOH and AME act as moderate xenoestrogens, but in silico modeling predicts further Alternaria toxins as potential estrogenic factors. Recent studies indicate also an immunosuppressive role of AOH and ATX-II; however, no data are available for the majority of Alternaria toxins. Overall, hazard characterization of Alternaria toxins focused, so far, primarily on the commercially available dibenzo-α-pyrones AOH and AME and tenuazonic acid (TeA). Limited data sets are available for altersetin (ALS), altenuene (ALT), and tentoxin (TEN). The occurrence and toxicological relevance of perylene quinone-based Alternaria toxins still remain to be fully elucidated. We identified data gaps on hazard identification and characterization crucial to improve risk assessment of Alternaria mycotoxins for consumers and occupationally exposed workers.pt_PT
dc.description.sponsorshipThe European Partnership for the Assessment of Risks from Chemicals has received funding from the European Union’s Horizon Europe research and innovation program under Grant Agreement No 101057014 and has received co-funding of the authors’ institutions. Views and opinions expressed are, however, those of the author(s) only and do not necessarily reflect those of the European Union or the Health and Digital Executive Agency. Neither the European Union nor the granting authority can be held responsible for them.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationArch Toxicol. 2023 Dec 26. doi: 10.1007/s00204-023-03636-8. Online ahead of print.pt_PT
dc.identifier.doi10.1007/s00204-023-03636-8pt_PT
dc.identifier.issn0340-5761
dc.identifier.urihttp://hdl.handle.net/10400.18/8818
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringerpt_PT
dc.relation101057014pt_PT
dc.relation.publisherversionhttps://link.springer.com/article/10.1007/s00204-023-03636-8pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectEnvironmental Genotoxicitypt_PT
dc.subjectAltenuenept_PT
dc.subjectAlternariolpt_PT
dc.subjectAltertoxinpt_PT
dc.subjectBiotransformationpt_PT
dc.subjectEndocrine Disruptionpt_PT
dc.subjectExposure Routespt_PT
dc.subjectGenotoxicitypt_PT
dc.subjectImmunosuppressionpt_PT
dc.subjectMycotoxinpt_PT
dc.subjectTentoxinpt_PT
dc.subjectTenuazonic Acidpt_PT
dc.subjectToxicokineticspt_PT
dc.subjectGenotoxicidade Ambientalpt_PT
dc.titleHazard characterization of Alternaria toxins to identify data gaps and improve risk assessment for human healthpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.titleArchives of Toxicologypt_PT
person.familyNameLouro
person.familyNameSilva
person.givenNameHenriqueta
person.givenNameMaria Joao
person.identifier157627
person.identifier.ciencia-id721D-2BB1-7DB1
person.identifier.ciencia-id7710-643D-97A3
person.identifier.orcid0000-0001-9744-7332
person.identifier.orcid0000-0002-6060-0716
person.identifier.scopus-author-id6507971479
person.identifier.scopus-author-id55944437600
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication2361a951-8b9a-4b90-92d6-f6384003a242
relation.isAuthorOfPublicationa7763685-7c34-468d-b958-9dd0aca66db4
relation.isAuthorOfPublication.latestForDiscoverya7763685-7c34-468d-b958-9dd0aca66db4

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