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I-MOVE multicentre case-control study 2010/11 to 2014/15: Is there within-season waning of influenza type/subtype vaccine effectiveness with increasing time since vaccination?

2016-04-21Artigo científico Acesso aberto
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dc.contributor.authorKissling, Esther
dc.contributor.authorNunes, Baltazar
dc.contributor.authorRobertson, Chris
dc.contributor.authorValenciano, Marta
dc.contributor.authorReuss, Annicka
dc.contributor.authorLarrauri, Amparo
dc.contributor.authorCohen, Jean Marie
dc.contributor.authorOroszi, Beatrix
dc.contributor.authorRizzo, Caterina
dc.contributor.authorMachado, Ausenda
dc.contributor.authorPitigoi, Daniela
dc.contributor.authorDomegan, Lisa
dc.contributor.authorParadowska-Stankiewicz, Iwona
dc.contributor.authorBuchholz, Udo
dc.contributor.authorGherasim, Alin
dc.contributor.authorDaviaud, Isabelle
dc.contributor.authorHorváth, Judit Krisztina
dc.contributor.authorBella, Antonino
dc.contributor.authorLupulescu, Emilia
dc.contributor.authorO Donnell, Joan
dc.contributor.authorKorczyńska, Monika
dc.contributor.authorMoren, Alain
dc.contributor.authorI-MOVE case–control study team
dc.date.accessioned2017-02-17T13:43:00Z
dc.date.available2017-02-17T13:43:00Z
dc.date.issued2016-04-21
dc.description.abstractSince the 2008/9 influenza season, the I-MOVE multicentre case-control study measures influenza vaccine effectiveness (VE) against medically-attended influenza-like-illness (ILI) laboratory confirmed as influenza. In 2011/12, European studies reported a decline in VE against influenza A(H3N2) within the season. Using combined I-MOVE data from 2010/11 to 2014/15 we studied the effects of time since vaccination on influenza type/subtype-specific VE. We modelled influenza type/subtype-specific VE by time since vaccination using a restricted cubic spline, controlling for potential confounders (age, sex, time of onset, chronic conditions). Over 10,000 ILI cases were included in each analysis of influenza A(H3N2), A(H1N1)pdm09 and B; with 4,759, 3,152 and 3,617 influenza positive cases respectively. VE against influenza A(H3N2) reached 50.6% (95% CI: 30.0-65.1) 38 days after vaccination, declined to 0% (95% CI: -18.1-15.2) from 111 days onwards. At day 54 VE against influenza A(H1N1)pdm09 reached 55.3% (95% CI: 37.9-67.9) and remained between this value and 50.3% (95% CI: 34.8-62.1) until season end. VE against influenza B declined from 70.7% (95% CI: 51.3-82.4) 44 days after vaccination to 21.4% (95% CI: -57.4-60.8) at season end. To assess if vaccination campaign strategies need revising more evidence on VE by time since vaccination is urgently needed.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationEuro Surveill. 2016;21(16):pii=30201. doi:10.2807/1560-7917.ES.2016.21.16.30201pt_PT
dc.identifier.doi10.2807/1560-7917.ES.2016.21.16.30201pt_PT
dc.identifier.issn1560-7917
dc.identifier.urihttp://hdl.handle.net/10400.18/4254
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherEuropean Centre for Disease Prevention and Control (ECDC)pt_PT
dc.relation.publisherversionhttp://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=21448pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/pt_PT
dc.subjectInfluenzapt_PT
dc.subjectinfluenza Viruspt_PT
dc.subjectVaccine-preventable Diseasespt_PT
dc.subjectVaccines and Immunisationpt_PT
dc.subjectEstados de Saúde e de Doençapt_PT
dc.subjectDeterminantes da Saúde e da Doençapt_PT
dc.titleI-MOVE multicentre case-control study 2010/11 to 2014/15: Is there within-season waning of influenza type/subtype vaccine effectiveness with increasing time since vaccination?pt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.titleEurosurveillancept_PT
oaire.citation.volume21(16)pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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