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Analysis of malaria associated genetic traits in Cabo Verde, a melting pot of European and sub Saharan settlers

2010-01-15Journal article Restricted access
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dc.contributor.authorAlves, Joana
dc.contributor.authorMachado, Patrícia
dc.contributor.authorSilva, João
dc.contributor.authorGonçalves, Nilza
dc.contributor.authorRibeiro, Letícia
dc.contributor.authorFaustino, Paula
dc.contributor.authorRosário, Virgílio Estólio do
dc.contributor.authorManco, Licínio
dc.contributor.authorGusmão, Leonor
dc.contributor.authorAmorim, António
dc.contributor.authorArez, Ana Paula
dc.date.accessioned2011-09-12T12:07:36Z
dc.date.available2011-09-12T12:07:36Z
dc.date.issued2010-01-15
dc.description.abstractMalaria has occurred in the Cabo Verde archipelago with epidemic characteristics since its colonization. Nowadays, it occurs in Santiago Island alone and though prophylaxis is not recommended by the World Health Organization, studies have highlight the prospect of malaria becoming a serious public health problem as a result of the presence of antimalarial drug resistance associated with mutations in the parasite populations and underscore the need for tighter surveillance. Despite the presumptive weak immune status of the population, severe symptoms of malaria are not observed and many people present a subclinical course of the disease. No data on the prevalence of sicklecell trait and red cell glucose-6-phosphate dehydrogenase deficiency (two classical genetic factors associated with resistance to severe malaria) were available for the Cabo Verde archipelago and, therefore, we studied the low morbidity from malaria in relation to the particular genetic characteristics of the human host population. We also included the analysis of the pyruvate kinase deficiency associated gene, reported as putatively associated with resistance to the disease. Allelic frequencies of the polymorphisms examined are closer to European than to African populations and no malaria selection signatures were found. No association was found between the analyzed human factors and infection but one result is of high interest: a linkage disequilibrium test revealed an association of distant loci in the PKLR gene and adjacent regions, only in non-infected individuals. This could mean a more conserved gene region selected in association to protection against the infection and/or the disease.por
dc.identifier.citationBlood Cells Mol Dis. 2010 Jan 15;44(1):62-8. Epub 2009 Oct 17por
dc.identifier.issn1079-9796
dc.identifier.otherdoi:10.1016/j.bcmd.2009.09.008
dc.identifier.urihttp://hdl.handle.net/10400.18/144
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherElsevierpor
dc.relation.publisherversionhttp://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6WBV-4XGCHXY-1-4&_cdi=6720&_user=2460193&_pii=S1079979609001752&_origin=&_coverDate=01%2F15%2F2010&_sk=999559998&view=c&wchp=dGLzVlz-zSkzV&md5=21ed902ea786acab8ce255c33febf851&ie=/sdarticle.pdfpor
dc.subjectHemoglobin Spor
dc.subjectGlucose-6-Phophate-dehydrogenasepor
dc.subjectPyruvate Kinasepor
dc.subjectCabo Verdepor
dc.subjectMalariapor
dc.subjectDoenças Genéticaspor
dc.titleAnalysis of malaria associated genetic traits in Cabo Verde, a melting pot of European and sub Saharan settlerspor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage68por
oaire.citation.startPage62por
oaire.citation.titleBlood Cells, Molecules and Diseasespor
rcaap.rightsrestrictedAccesspor
rcaap.typearticlepor

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