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Estrogen catechols detection as biomarkers in schistosomiasis induced cancer and infertility

2017-01Journal article Open access
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dc.contributor.authorBotelho, M.C.
dc.contributor.authorAlves, H.
dc.contributor.authorRichter, J.
dc.date.accessioned2017-11-03T16:53:27Z
dc.date.available2017-11-03T16:53:27Z
dc.date.issued2017-01
dc.description.abstractUrogenital schistosomiasis is a chronic infection caused by the human blood fluke Schistosoma haematobium. Schistosomiasis haematobium is a known risk factor for cancer leading to squamous cell carcinoma of the urinary bladder (SCC). This is a neglected tropical disease endemic in many countries of Africa and the Middle East. Schistosome eggs produce catechol-estrogens. These molecules are metabolized to active quinones that cause alterations in DNA (leading in other contexts to breast or thyroid cancer). Our group have shown that schistosome egg associated catechol estrogens induce tumor-like phenotypes in urothelial cells, originated from parasite estrogen-host cell chromosomal DNA adducts and mutations. Here we review recent findings on the role of estrogen-DNA adducts and how their shedding in urine may be prognostic of schistosome infection and/or represent potential biomarkers for urogenital schistosomiasis associated bladder cancer and infertility.pt_PT
dc.description.sponsorshipThis work was financed by FEDER - Fundo Europeu de Desenvolvimento Regional funds through the COMPETE 2020 - Operacional Programme for Competitiveness and Internationalisation (POCI), Portugal 2020, and by Portuguese funds through FCT - Fundação para a Ciência e a Tecnologia/ Ministério da Ciência, Tecnologia e Inovação in the framework of the project "Institute for Research and Innovation in Health Sciences" (POCI-01-0145-FEDER-007274).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationLett Drug Des Discov. 2017;14(2):135-138.pt_PT
dc.identifier.issn1570-1808
dc.identifier.urihttp://hdl.handle.net/10400.18/4821
dc.language.isoengpt_PT
dc.publisherSM Grouppt_PT
dc.relation.publisherversionhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5179139/pt_PT
dc.subjectBiomarkerspt_PT
dc.subjectBladder Cancerpt_PT
dc.subjectEstrogen Metabolitespt_PT
dc.subjectInfertilitypt_PT
dc.subjectSchistosoma Haematobiumpt_PT
dc.titleEstrogen catechols detection as biomarkers in schistosomiasis induced cancer and infertilitypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FBIM%2F04293%2F2013/PT
oaire.citation.endPage138pt_PT
oaire.citation.issue2pt_PT
oaire.citation.startPage135pt_PT
oaire.citation.titleLetters in Drug Design and Discoverypt_PT
oaire.citation.volume14pt_PT
oaire.fundingStream5876
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isProjectOfPublicationfa9009ed-65e1-4108-bd20-1304211124ea
relation.isProjectOfPublication.latestForDiscoveryfa9009ed-65e1-4108-bd20-1304211124ea

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