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Effect of indoor air quality of day care centers in children with different predisposition for asthma

2015-12-06Journal article Restricted access
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dc.contributor.authorCarreiro-Martins, Pedro
dc.contributor.authorPapoila, Ana Luisa
dc.contributor.authorCaires, Iolanda
dc.contributor.authorAzevedo, Susana
dc.contributor.authorCano, Maria Manuela
dc.contributor.authorVirella, Daniel
dc.contributor.authorLeiria-Pinto, Paula
dc.contributor.authorTeixeira, João Paulo
dc.contributor.authorRosado-Pinto, José
dc.contributor.authorAnnesi Maesano, Isabella
dc.contributor.authorNeuparth, Nuno
dc.date.accessioned2016-03-11T12:25:57Z
dc.date.available2018-01-01T01:30:10Z
dc.date.issued2015-12-06
dc.description.abstractBACKGROUND: Scarce information is available about the relationships between indoor air quality (IAQ) at day care centers (DCC), the estimated predisposition for asthma and the actual wheezing susceptibility. METHODS: In the Phase II of ENVIRH study, 19 DCC were recruited after cluster analysis. Children were evaluated firstly using the ISAAC questionnaire and later by a follow up questionnaire about recent wheezing. A positive asthma predictive index (API) was considered as predisposition for asthma. Every DCC was audited for IAQ and monitored for chemical and biological contaminants. RESULTS: We included 1,191 children, with a median age of 43 (P25 -P75 : 25-58) months. Considering the overall sample, in the first questionnaire, associations were found between CO2 concentration (increments of 200 ppm) and diagnosis of asthma (OR: 1.10; 95% CI: 1.00 - 1.20). Each increment of 100 μg.m-3 of total volatile organic compounds (TVOC) and 1 μg of Der p1/g of dust were associated with wheezing in the previous 12 months (OR: 1.06; 95% CI: 1.01-1.11 and OR: 1.06; 95% CI: 0.99-1.12, respectively). In the follow-up questionnaire, TVOC were again associated with wheezing (OR: 1.05; 95% CI: 1.00-1.11). Children exposed to fungal concentration above the 75th percentile had also higher odds of wheezing at follow-up. TVOC were associated with wheezing in children with either negative or positive API. CONCLUSIONS: IAQ in DCC seems to be associated with wheezing, in children with and without predisposition for asthma. This article is protected by copyright. All rights reserved.pt_PT
dc.description.sponsorshipFCTpt_PT
dc.identifier.citationPediatr Allergy Immunol. 2016 May;27(3):299-306. doi: 10.1111/pai.12521. Epub 2016 Jan 26pt_PT
dc.identifier.doi10.1111/pai.12521pt_PT
dc.identifier.issn0905-6157
dc.identifier.urihttp://hdl.handle.net/10400.18/3688
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherJohn Wiley & Sonspt_PT
dc.relation.publisherversionhttp://onlinelibrary.wiley.com/doi/10.1111/pai.12521/fullpt_PT
dc.subjectAsthmapt_PT
dc.subjectAsthma Predictive Indexpt_PT
dc.subjectDay Care Centerpt_PT
dc.subjectIndoor Air Qualitypt_PT
dc.subjectVolitile Organic Compoundspt_PT
dc.subjectWheezingpt_PT
dc.subjectAr e Saúde Ocupacionalpt_PT
dc.titleEffect of indoor air quality of day care centers in children with different predisposition for asthmapt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FSAU-ESA%2F100275%2F2008/PT
oaire.citation.endPage8pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titlePediatric Allergy and Immunologypt_PT
oaire.fundingStream3599-PPCDT
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsembargoedAccesspt_PT
rcaap.typearticlept_PT
relation.isProjectOfPublication5ffceb17-2386-487a-a9ad-1f3363444c19
relation.isProjectOfPublication.latestForDiscovery5ffceb17-2386-487a-a9ad-1f3363444c19

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