Bracketing versus multipoint calibration in determination of isocyanates in agglomerated cork stoppers

Delgado, I.; André, C.; Ramos, A.; Matos, A.S.; Stockham, K.; Kumaran, S.; Castanheira, I.

http://hdl.handle.net/10400.18/1272

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Abstract(s)

A calibration method was developed for the quantification of isocyanates in cork stoppers agglomerates. Bracketing and multipoint calibration curve was applied to a in-house optimized UPLC/DAD analytical method. The calibration curves were obtained by regression analysis using experimental points that covers the range of concentrations expected in real samples. A contaminated real sample was injected and MDI concentration was 6.2 % and 6.4% when calibration methods to calculate the content were multipoint or bracketing, respectively. According with our results both methods are complementary and necessary to guarantee the reliably of results obtained by chromatographic procedure.