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The Impact of Perfluorooctanoic Acid (PFOA) on the Mussel Mytilus galloprovincialis: A Multi-Biomarker Evaluation

2024-11-05Journal article Open access
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dc.contributor.authorCopeto, Sandra
dc.contributor.authorGanço, Sara
dc.contributor.authorFerreira, Inês João
dc.contributor.authorSanchez, Didier
dc.contributor.authorNunes, Maria João
dc.contributor.authorMotta, Carla
dc.contributor.authorSilva, Marco
dc.contributor.authorDiniz, Mário
dc.date.accessioned2025-03-11T14:24:19Z
dc.date.available2025-03-11T14:24:19Z
dc.date.issued2024-11-05
dc.description.abstractPerfluorooctanoic acid (PFOA) has been widely studied due to its environmental persistence and bioaccumulation potential, raising concerns about its effects on aquatic life. This research evaluates the impact of PFOA on the antioxidant defenses and stress response systems of the mussel Mytilus galloprovincialis. Mussels were exposed to three concentrations of PFOA (1, 10, and 100 µg·L−1) over 28 days. Several biomarkers, including glutathione S-transferase (GST), superoxide dismutase (SOD), catalase (CAT), lipid peroxidation (LPO), total antioxidant capacity (TAC), vitellogenin (VTG), ubiquitin (UBI), and caspase-3 (CASP) were analyzed. The results suggest stress responses, particularly in animals exposed to higher concentrations, as shown by GST and SOD activities which increased according to PFOA concentrations. Additionally, oxidative stress markers such as MDA and CAT showed variable responses depending on the exposure concentration tested. This study underscores the need for further investigation into the effects of PFOA on mollusks but also the need to unveil gender-specific responses in aquatic organisms exposed to this contaminant. The concentrations of PFOA used in our research are lower than those examined in previous studies, providing crucial insights into the impacts of even minimal exposure levels. It highlights the potential of M. galloprovincialis as a bioindicator in environmental monitoring programs, providing crucial insights for environmental management and policymaking regarding regulating and monitoring PFOA in marine settings. Consequently, in a country where seafood consumption is the second largest in Europe, implementing environmental policies and regulatory measures to manage and monitor PFOA levels in marine environments is crucial.eng
dc.description.sponsorshipThis work was funded by national funds from FCT—Fundação para a Ciência e a Tecnologia, I.P., in the scope of the project UIDP/04378/2020 and UIDB/04378/2020 of the Research Unit on Applied Molecular Biosciences—UCIBIO and the project LA/P/0140/2020 of the Associate Laboratory In-stitute for Health and Bioeconomy—i4HB and by the Associate Laboratory for Green Chemistry—LAQV which is financed by national funds from FCT/MCTES (UID/QUI/50006/2019). This work was also conducted under the Horizon Eurizon project “Prevent Groundwater Contamination Related to Global and Climate Change Through a Holistic approach based on Managed Aqiofer Recharge”, “MAR2PROTECT” (CL6-2022-ZEROPOLLUTION-01-01).
dc.identifier.citationOceans. 2024 November 5;5(4):857-873. doi: 10.3390/oceans5040049
dc.identifier.doi10.3390/oceans5040049
dc.identifier.issn2673-1924
dc.identifier.urihttp://hdl.handle.net/10400.18/10430
dc.language.isoeng
dc.peerreviewedyes
dc.publisherMDPI
dc.relationApplied Molecular Biosciences Unit
dc.relationApplied Molecular Biosciences Unit
dc.relationInstitute for Health and Bioeconomy
dc.relationAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
dc.relation.hasversionhttps://www.mdpi.com/2673-1924/5/4/49
dc.relation.ispartofOceans
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectPerfluorooctanoic Acid (PFOA)
dc.subjectMytilus galloprovincialis
dc.subjectAntioxidant Defense
dc.subjectOxidative Stress
dc.subjectEndocrine Disruptors
dc.subjectEnvironmental Monitoring
dc.subjectSegurança Alimentar
dc.titleThe Impact of Perfluorooctanoic Acid (PFOA) on the Mussel Mytilus galloprovincialis: A Multi-Biomarker Evaluationeng
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleApplied Molecular Biosciences Unit
oaire.awardTitleApplied Molecular Biosciences Unit
oaire.awardTitleInstitute for Health and Bioeconomy
oaire.awardTitleAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F04378%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04378%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0140%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FQUI%2F50006%2F2019/PT
oaire.citation.endPage873
oaire.citation.issue4
oaire.citation.startPage857
oaire.citation.titleOceans
oaire.citation.volume5
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
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project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
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