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Interactive effects of ambient fine particulate matter and ozone on daily mortality in 372 cities: two stage time series analysis

2023-10-04Journal article Restricted access
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dc.contributor.authorLiu, Cong
dc.contributor.authorChen, Renjie
dc.contributor.authorSera, Francesco
dc.contributor.authorVicedo-Cabrera, Ana Maria
dc.contributor.authorGuo, Yuming
dc.contributor.authorTong, Shilu
dc.contributor.authorLavigne, Eric
dc.contributor.authorCorrea, Patricia Matus
dc.contributor.authorOrtega, Nicolás Valdés
dc.contributor.authorAchilleos, Souzana
dc.contributor.authorRoye, Dominic
dc.contributor.authorJaakkola, Jouni J.K.
dc.contributor.authorRyti, Niilo
dc.contributor.authorPascal, Mathilde
dc.contributor.authorSchneider, Alexandra
dc.contributor.authorBreitner, Susanne
dc.contributor.authorEntezari, Alireza
dc.contributor.authorMayvaneh, Fatemeh
dc.contributor.authorRaz, Raanan
dc.contributor.authorHonda, Yasushi
dc.contributor.authorHashizume, Masahiro
dc.contributor.authorNg, Chris Fook Sheng
dc.contributor.authorGaio, Vânia
dc.contributor.authorMadureira, Joana
dc.contributor.authorHolobaca, Iulian-Horia
dc.contributor.authorTobias, Aurelio
dc.contributor.authorÍñiguez, Carmen
dc.contributor.authorGuo, Yue Leon
dc.contributor.authorPan, Shih-Chun
dc.contributor.authorMasselot, Pierre
dc.contributor.authorBell, Michelle L.
dc.contributor.authorZanobetti, Antonella
dc.contributor.authorSchwartz, Joel
dc.contributor.authorGasparrini, Antonio
dc.contributor.authorKan, Haidong
dc.date.accessioned2023-11-28T15:02:54Z
dc.date.available2023-11-28T15:02:54Z
dc.date.issued2023-10-04
dc.description.abstractObjective: To investigate potential interactive effects of fine particulate matter (PM2.5) and ozone (O3) on daily mortality at global level. Design: Two stage time series analysis. Setting: 372 cities across 19 countries and regions. Population: Daily counts of deaths from all causes, cardiovascular disease, and respiratory disease. Main outcome measure: Daily mortality data during 1994-2020. Stratified analyses by co-pollutant exposures and synergy index (>1 denotes the combined effect of pollutants is greater than individual effects) were applied to explore the interaction between PM2.5 and O3 in association with mortality. Results: During the study period across the 372 cities, 19.3 million deaths were attributable to all causes, 5.3 million to cardiovascular disease, and 1.9 million to respiratory disease. The risk of total mortality for a 10 μg/m3 increment in PM2.5 (lag 0-1 days) ranged from 0.47% (95% confidence interval 0.26% to 0.67%) to 1.25% (1.02% to 1.48%) from the lowest to highest fourths of O3 concentration; and for a 10 μg/m3 increase in O3 ranged from 0.04% (-0.09% to 0.16%) to 0.29% (0.18% to 0.39%) from the lowest to highest fourths of PM2.5 concentration, with significant differences between strata (P for interaction <0.001). A significant synergistic interaction was also identified between PM2.5 and O3 for total mortality, with a synergy index of 1.93 (95% confidence interval 1.47 to 3.34). Subgroup analyses showed that interactions between PM2.5 and O3 on all three mortality endpoints were more prominent in high latitude regions and during cold seasons. Conclusion: The findings of this study suggest a synergistic effect of PM2.5 and O3 on total, cardiovascular, and respiratory mortality, indicating the benefit of coordinated control strategies for both pollutants.pt_PT
dc.description.sponsorshipHK, RC, and CL were supported by the National Natural Science Foundation of China (92043301, 82030103, and 82103790). FS was supported by the Italian Ministry of University and Research, Department of Excellence project 2023-2027 ReDS “Rethinking Data Science” - Department of Statistics, Computer Science and Applications - University of Florence.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationBMJ. 2023 Oct 4:383:e075203. doi: 10.1136/bmj-2023-075203.pt_PT
dc.identifier.doi10.1136/bmj-2023-075203pt_PT
dc.identifier.issn1759-2151
dc.identifier.urihttp://hdl.handle.net/10400.18/8793
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherBMJ Publishing Grouppt_PT
dc.relation.publisherversionhttps://www.bmj.com/content/383/bmj-2023-075203.longpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/pt_PT
dc.subjectParticulate Matterpt_PT
dc.subjectOzonept_PT
dc.subjectAir Pollutionpt_PT
dc.subjectAir Pollutantspt_PT
dc.subjectEnvironmental Exposurept_PT
dc.subjectMortalitypt_PT
dc.subjectHumanspt_PT
dc.subjectRespiration Disorderspt_PT
dc.subjectCitiespt_PT
dc.subjectDeterminantes da Saúde e da Doençapt_PT
dc.subjectEstados de Saúde e de Doençapt_PT
dc.subjectAvaliação do Riscopt_PT
dc.titleInteractive effects of ambient fine particulate matter and ozone on daily mortality in 372 cities: two stage time series analysispt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.startPagee075203pt_PT
oaire.citation.titleBMJpt_PT
person.familyNameGaio
person.givenNameVânia
person.identifier.ciencia-idA71A-17AF-30C7
person.identifier.orcid0000-0001-7626-4991
person.identifier.scopus-author-id56080468200
rcaap.embargofctAcesso de acordo com a política editorial da revistas.pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication59791814-187c-4b34-b3a2-6ad67a213814
relation.isAuthorOfPublication.latestForDiscovery59791814-187c-4b34-b3a2-6ad67a213814

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