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Mapping the evidence of the effects of environmental factors on the prevalence of antibiotic resistance in the non-built environment

2025-07-27Artigo científico Acesso aberto
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dc.contributor.authorDeza-Cruz, Iñaki
dc.contributor.authorde Menezes, Alexandre
dc.contributor.authorGardner, Brian
dc.contributor.authorAktan, Ílknur
dc.contributor.authorAlnajjar, Sarhad
dc.contributor.authorBetson, Martha
dc.contributor.authorCabal Rosel, Adriana
dc.contributor.authorCaniça, Manuela
dc.contributor.authorChambers, Mark A.
dc.contributor.authorTarrant, Georgina
dc.contributor.authorContadini, Francesca
dc.contributor.authorDaramola, Olukayode
dc.contributor.authorde la Rivière, Rani
dc.contributor.authorEgan, Bernadette
dc.contributor.authorEkiri, Abel
dc.contributor.authorFinnegan, Catherine
dc.contributor.authorGonzalez Villeta, Laura C.
dc.contributor.authorGreen, Richard
dc.contributor.authorHall, Belinda
dc.contributor.authorHassan, Marwa M.
dc.contributor.authorHawes, Martin
dc.contributor.authorHealy, Sara
dc.contributor.authorHolbrook, Lisa
dc.contributor.authorKaya, Damla
dc.contributor.authorKumar, Prashant
dc.contributor.authorLa Ragione, Roberto M.
dc.contributor.authorMaupin, Daniel
dc.contributor.authorMehat, Jai W.
dc.contributor.authorMessina, Davide
dc.contributor.authorMoon, Kelly
dc.contributor.authorMumford, Elizabeth
dc.contributor.authorNichols, Gordon
dc.contributor.authorOlivença, Daniel V.
dc.contributor.authorPrada, Joaquin M.
dc.contributor.authorPrice, Claire
dc.contributor.authorProudman, Christopher
dc.contributor.authorQueenan, Retha
dc.contributor.authorRamos, Miguel
dc.contributor.authorClosa, Jaime Riccomini
dc.contributor.authorRitchie, Jennifer M.
dc.contributor.authorSantorelli, Lorenzo A.
dc.contributor.authorSelemetas, Nick
dc.contributor.authorSpick, Matt
dc.contributor.authorSubbannayya, Yashwanth
dc.contributor.authorSurendran, Shelini
dc.contributor.authorTeixeira, Pedro
dc.contributor.authorTharmakulasingam, Mukunthan
dc.contributor.authorValle, Damian
dc.contributor.authorvan Vliet, Arnoud H.M.
dc.contributor.authorVideira, Marco
dc.contributor.authorWallace-Williams, Hazel
dc.contributor.authorWanelik, Klara M.
dc.contributor.authorWoegerbauer, Markus
dc.contributor.authorWright, Sydney
dc.contributor.authorLo Iacono, Giovanni
dc.date.accessioned2026-02-06T13:50:46Z
dc.date.available2026-02-06T13:50:46Z
dc.date.issued2025-07-27
dc.description.abstractBackground: Antibiotic resistance increasingly threatens the interconnected health of humans, animals, and the environment. While misuse of antibiotics is a known driver, environmental factors also play a critical role. A balanced One Health approach-including the environmental sector-is necessary to understand the emergence and spread of resistance. Methods: We systematically searched English-language literature (1990-2021) in MEDLINE, Embase, and Web of Science, plus grey literature. Titles, abstracts, and keywords were screened, followed by full-text reviews using a structured codebook and dual-reviewer assessments. Results: Of 13,667 records screened, 738 met the inclusion criteria. Most studies focused on freshwater and terrestrial environments, particularly associated with wastewater or manure sources. Evidence of research has predominantly focused on Escherichia coli and Pseudomonas spp., with a concentration on ARGs conferring resistance to sulphonamides (sul1-3), tetracyclines (tet), and beta-lactams. Additionally, the People's Republic of China has produced a third of the studies-twice that of the next country, the United States-and research was largely domestic, with closely linked author networks. Conclusion: Significant evidence gaps persist in understanding antibiotic resistance in non-built environments, particularly in marine, atmospheric, and non-agricultural settings. Stressors such as climate change and microplastics remain notably under-explored. There is also an urgent need for more research in low-income regions, which face higher risks of antibiotic resistance, to support the development of targeted, evidence-based interventions.eng
dc.description.sponsorshipThis work was mainly supported by funding from the European Union’s Horizon 2020 Research and Innovation programme under grant agreement No 773830: One Health European Joint Programme (FED-AMR project). This work was also partly co-funded by the European Union’s Horizon Europe Project 101136346 EUPAHW. PK acknowledges the support received from the UK Research and Innovation (UKRI) funded project RECLAIM Network Plus (EP/W034034/1).
dc.identifier.citationEnviron Int. 2025 Aug:202:109634. doi: 10.1016/j.envint.2025.109634. Epub 2025 Jul 27
dc.identifier.doi10.1016/j.envint.2025.109634
dc.identifier.eissn1873-6750
dc.identifier.issn0160-4120
dc.identifier.pmid40753756
dc.identifier.urihttp://hdl.handle.net/10400.18/10827
dc.language.isoeng
dc.peerreviewedyes
dc.publisherElsevier
dc.relationPromoting One Health in Europe through joint actions on foodborne zoonoses, antimicrobial resistance and emerging microbiological hazards.
dc.relationEuropean Partnership Animal health and Welfare
dc.relation.hasversionhttps://www.sciencedirect.com/science/article/pii/S016041202500385X?via%3Dihub
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectARB
dc.subjectARG
dc.subjectAntibiotic Resistance Gene
dc.subjectAntibiotic Resistant Bacteria
dc.subjectEnvironment
dc.subjectOne Health
dc.subjectSEM
dc.subjectSystematic Evidence Mapping
dc.subjectResistência aos Antimicrobianos
dc.titleMapping the evidence of the effects of environmental factors on the prevalence of antibiotic resistance in the non-built environmenteng
dc.typejournal article
dcterms.referenceshttps://www.sciencedirect.com/science/article/pii/S016041202500385X?via%3Dihub#appSB
dspace.entity.typePublication
oaire.awardTitlePromoting One Health in Europe through joint actions on foodborne zoonoses, antimicrobial resistance and emerging microbiological hazards.
oaire.awardTitleEuropean Partnership Animal health and Welfare
oaire.awardURIinfo:eu-repo/grantAgreement/EC/H2020/773830/EU
oaire.awardURIhttp://hdl.handle.net/10400.18/10826
oaire.citation.startPage109634
oaire.citation.titleEnvironment International
oaire.citation.volume202
oaire.fundingStreamH2020
oaire.fundingStreamHORIZON Programme Cofund Actions
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.nameEuropean Commission
relation.isProjectOfPublication94d118fb-33ce-49fa-b1ed-d5bddf63581d
relation.isProjectOfPublication9be7ad51-a201-4d60-9319-a6c576f5202f
relation.isProjectOfPublication.latestForDiscovery94d118fb-33ce-49fa-b1ed-d5bddf63581d

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