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Biomarkers of effect as determined in human biomonitoring studies on hexavalent chromium and cadmium in the period 2008-2020

2021-06Journal article Open access
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dc.contributor.authorVentura, Célia
dc.contributor.authorGomes, BC
dc.contributor.authorOberemm, Axel
dc.contributor.authorLouro, Henriqueta
dc.contributor.authorHuuskonen, Pasi
dc.contributor.authorMustieles, Vicente
dc.contributor.authorFernández, Mariana F.
dc.contributor.authorNdaw, Sophie
dc.contributor.authorMengelers, Marcel
dc.contributor.authorLuijten, Mirjam
dc.contributor.authorGundacker, Claudia
dc.contributor.authorSilva, Maria João
dc.date.accessioned2022-01-10T15:45:51Z
dc.date.available2022-01-10T15:45:51Z
dc.date.issued2021-06
dc.descriptionReviewpt_PT
dc.description.abstractA number of human biomonitoring (HBM) studies have presented data on exposure to hexavalent chromium [Cr(VI)] and cadmium (Cd), but comparatively few include results on effect biomarkers. The latter are needed to identify associations between exposure and adverse outcomes (AOs) in order to assess public health implications. To support improved derivation of EU regulation and policy making, it is of great importance to identify the most reliable effect biomarkers for these heavy metals that can be used in HBM studies. In the framework of the Human Biomonitoring for Europe (HBM4EU) initiative, our study aim was to identify effect biomarkers linking Cr(VI) and Cd exposure to selected AOs including cancer, immunotoxicity, oxidative stress, and omics/epigenetics. A comprehensive PubMed search identified recent HBM studies, in which effect biomarkers were examined. Validity and applicability of the markers in HBM studies are discussed. The most frequently analysed effect biomarkers regarding Cr(VI) exposure and its association with cancer were those indicating oxidative stress (e.g., 8-hydroxy-2’-deoxyguanosine (8-OHdG), malondialdehyde (MDA), glutathione (GSH)) and DNA or chromosomal damage (comet and micronucleus assays). With respect to Cd and to some extent Cr, β-2-microglobulin (B2-MG) and N-acetyl-β-D-glucosaminidase (NAG) are well-established, sensitive, and the most common effect biomarkers to relate Cd or Cr exposure to renal tubular dysfunction. Neutrophil gelatinase-associated lipocalin (NGAL) and kidney injury molecule (KIM)-1 could serve as sensitive biomarkers of acute kidney injury in response to both metals, but need further investigation in HBM studies. Omics-based biomarkers, i.e., changes in the (epi-)genome, transcriptome, proteome, and metabolome associated with Cr and/or Cd exposure, are promising effect biomarkers, but more HBM data are needed to confirm their significance. The combination of established effect markers and omics biomarkers may represent the strongest approach, especially if based on knowledge of mechanistic principles. To this aim, also mechanistic data were collected to provide guidance on the use of more sensitive and specific effect biomarkers. This also led to the identification of knowledge gaps relevant to the direction of future research.pt_PT
dc.description.sponsorshipThis research was supported by funding from the European Union´s Horizon 2020 research and innovation Programme under grant agreement No 733032 HBM4EUpt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationEnviron Res. 2021 Jun;197:110998. doi: 10.1016/j.envres.2021.110998. Epub 2021 Mar 11. Reviewpt_PT
dc.identifier.doi10.1016/j.envres.2021.110998pt_PT
dc.identifier.issn0013-9351
dc.identifier.urihttp://hdl.handle.net/10400.18/7840
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevier/ Academic Presspt_PT
dc.relationEuropean Human Biomonitoring Initiative
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0013935121002929?via%3Dihubpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectToxic Metalspt_PT
dc.subjectEnvironmental Genotoxicitypt_PT
dc.subjectHuman Biomonitoringpt_PT
dc.subjectEffect biomarkerspt_PT
dc.subjectHexavalent chromiumpt_PT
dc.subjectCancerpt_PT
dc.subjectOxidative Stresspt_PT
dc.subjectNephrotoxicitypt_PT
dc.subjectImmunotoxicitypt_PT
dc.subjectMode of Actionpt_PT
dc.subjectAdverse Outcome Pathwaypt_PT
dc.subjectGenotoxicidade Ambientalpt_PT
dc.titleBiomarkers of effect as determined in human biomonitoring studies on hexavalent chromium and cadmium in the period 2008-2020pt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleEuropean Human Biomonitoring Initiative
oaire.awardURIinfo:eu-repo/grantAgreement/EC/H2020/733032/EU
oaire.citation.startPage110998pt_PT
oaire.citation.titleEnvironmental Researchpt_PT
oaire.citation.volume197pt_PT
oaire.fundingStreamH2020
person.familyNameVentura
person.familyNameGomes
person.familyNameLouro
person.familyNameSilva
person.givenNameCélia
person.givenNameBruno
person.givenNameHenriqueta
person.givenNameMaria Joao
person.identifier2056460
person.identifier157627
person.identifier.ciencia-id6116-89BA-C617
person.identifier.ciencia-id1110-883F-9181
person.identifier.ciencia-id721D-2BB1-7DB1
person.identifier.ciencia-id7710-643D-97A3
person.identifier.orcid0000-0002-0637-2222
person.identifier.orcid0000-0002-5632-1095
person.identifier.orcid0000-0001-9744-7332
person.identifier.orcid0000-0002-6060-0716
person.identifier.scopus-author-id6507971479
person.identifier.scopus-author-id55944437600
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.nameEuropean Commission
rcaap.embargofctAcesso de acordo com política editorial da revista.pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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