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New bioelectrical impedance analysis equations for children and adolescents based on the deuterium dilution technique

2021-05-22Journal article Open access
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dc.contributor.authorKourkoumelis, Nikolaos
dc.contributor.authorGrujic, Vesna Rudic
dc.contributor.authorGrabez, Milkica
dc.contributor.authorVidic, Alfred
dc.contributor.authorSiksna, Inese
dc.contributor.authorLazda, Ilva
dc.contributor.authorBajić, Borko
dc.contributor.authorĐurović, Dijana
dc.contributor.authorSpiroski, Igor
dc.contributor.authorDimitrovska, Maja
dc.contributor.authorRito, Ana
dc.contributor.authorMendes, Sofia
dc.contributor.authorKæstel, Pernille
dc.contributor.authorWard, Leigh C.
dc.date.accessioned2022-02-17T16:35:35Z
dc.date.available2022-02-17T16:35:35Z
dc.date.issued2021-05-22
dc.description.abstractBackground and aims: Body composition in childhood is not only a marker of the prevalence of obesity, but it can also be used to assess associated metabolic complications. Bioelectrical impedance analysis (BIA) shows promise as an easy to use, rapid, and non-invasive tool to evaluate body composition. The objectives of this study were to: (a) develop BIA prediction equations to estimate total body water (TBW) and fat-free mass (FFM) in European children and early adolescents and to validate the analysis with the deuterium dilution as the reference technique and (b) compare our results with previously published paediatric BIA equations. Methods: The cohort included 266 healthy children and adolescents between 7 and 14 years of age, 46% girls, in five European countries: Bosnia and Herzegovina, Latvia, Montenegro, North Macedonia, and Portugal. TBW and FFM were the target variables in the developed regression models. For model development, the dataset was randomly split into training and test sets, in 70:30 ratio, respectively. Model tuning was performed with 10-fold cross-validation that confirmed the unbiased estimate of its performance. The final regression models were retrained on the whole dataset. Results: Cross-validated regression models were developed using resistance index, weight, and sex as the optimal predictors. The new prediction equations explained 87% variability in both TBW and FFM. Limits of agreement between BIA and reference values, were within ±17% of the mean, ( 3.4, 3.7) and ( 4.5, 4.8) kg for TBW and FFM, respectively. BIA FFM and TBW estimates were within one standard deviation for approximately 83% of the children. BIA prediction equations underestimated TBW and FFM by 0.2 kg and 0.1 kg respectively with no proportional bias and comparable accuracy among different BMI-for-age subgroups. Comparison with predictive equations from published studies revealed varying discrepancy rates with the deuterium dilution measurements, with only two being equivalent to the equations developed in this study. Conclusions: The small difference between deuterium dilution and BIA measurements validated by Bland e Altman analysis, supports the application of BIA for epidemiological studies in European children using the developed equations.pt_PT
dc.description.sponsorshipThis research was funded by the International Atomic Energy Agency [grant number RER6034].pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationClin Nutr ESPEN. 2021 Aug;44:402-409. doi: 10.1016/j.clnesp.2021.05.001. Epub 2021 May 22pt_PT
dc.identifier.doi10.1016/j.clnesp.2021.05.001pt_PT
dc.identifier.issn2405-4577
dc.identifier.urihttp://hdl.handle.net/10400.18/7956
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relation.publisherversionhttps://clinicalnutritionespen.com/article/S2405-4577(21)00181-9/fulltextpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectBioelectrical Impedance Analysispt_PT
dc.subjectBody Compositionpt_PT
dc.subjectChildrenpt_PT
dc.subjectDeuterium Dilutionpt_PT
dc.subjectEstilos de Vida e Impacto na Saúdept_PT
dc.subjectSaúde Públicapt_PT
dc.titleNew bioelectrical impedance analysis equations for children and adolescents based on the deuterium dilution techniquept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage409pt_PT
oaire.citation.startPage402pt_PT
oaire.citation.titleClinical Nutrition ESPENpt_PT
oaire.citation.volume44pt_PT
rcaap.embargofctAcesso de acordo com página web do editor da revista.pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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