Publication
Natural polymorphisms of HIV type 2 pol sequences from drug-naive individuals
| dc.contributor.author | Parreira, R. | |
| dc.contributor.author | Monteiro, F. | |
| dc.contributor.author | Pádua, E. | |
| dc.contributor.author | Piedade, J. | |
| dc.contributor.author | Venenno, T. | |
| dc.contributor.author | Paixão, M.T. | |
| dc.contributor.author | Esteves, A. | |
| dc.date.accessioned | 2013-05-24T17:11:53Z | |
| dc.date.available | 2013-05-24T17:11:53Z | |
| dc.date.issued | 2006-11 | |
| dc.description.abstract | Until today, the susceptibility of human immunodeficiency virus type 2 (HIV-2) to protease and nucleosidic reverse-transcriptase inhibitors (PI and NRTI, respectively) has not been clearly documented. In this report we studied HIV-2 proviral sequences (n = 30) from drug-naive patients. Our results revealed that several amino acid positions in the protease and reverse transcriptase coding sequence harbored residues that have been associated with drug resistance in HIV-1-infected patients. In particular, the M46I substitution in the protease was detected in 90% of the sequences analyzed, which, together with the other substitutions identified, may indicate a reduced susceptibility of HIV-2-infected drug-naive patients to PI. Furthermore, interpretation of genotypic data with four available algorithms, developed for interpretation of HIV-1 sequence data, suggested nonoverlapping profiles of drug resistance. | por |
| dc.identifier.citation | AIDS Res Hum Retroviruses. 2006 Nov;22(11):1178-82 | por |
| dc.identifier.issn | 0889-2229 | |
| dc.identifier.uri | http://hdl.handle.net/10400.18/1587 | |
| dc.language.iso | eng | por |
| dc.peerreviewed | yes | por |
| dc.publisher | Mary Ann Liebert / International Retrovirology Association | por |
| dc.relation.publisherversion | http://online.liebertpub.com/doi/abs/10.1089/aid.2006.22.1178 | por |
| dc.subject | HIV-2 | por |
| dc.subject | Pol Sequences | por |
| dc.subject | Polymorphisms | por |
| dc.subject | Drug-naive | por |
| dc.subject | Portugal | por |
| dc.subject | Infecções Sexualmente Transmissíveis | por |
| dc.title | Natural polymorphisms of HIV type 2 pol sequences from drug-naive individuals | por |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.endPage | 1182 | por |
| oaire.citation.startPage | 1178 | por |
| oaire.citation.title | AIDS Research and Human Retroviruses | por |
| oaire.citation.volume | 22(11): | por |
| rcaap.rights | openAccess | por |
| rcaap.type | article | por |