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Esophageal cancer in Mozambique: should mycotoxins be a concern?

2019-07-11Journal article Restricted access
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dc.contributor.authorCome, Jotamo
dc.contributor.authorCambaza, Edgar
dc.contributor.authorFerreira, Rita
dc.contributor.authorda Costa, José Manuel Correia
dc.contributor.authorCarrilho, Carla
dc.contributor.authorSantos, Lúcio Lara
dc.date.accessioned2020-05-06T11:21:45Z
dc.date.available2020-05-06T11:21:45Z
dc.date.issued2019-07-11
dc.description.abstractFumonisin B1 (FB1) is a mycotoxin frequently found in agricultural commodities. The toxin poses a considerable risk for human and animal health. FB1 is among several mycotoxins produced by Fusarium spp. contaminating virtually any cereal and other Poaceae. Their intracellular action includes the promotion of oxidative stress through the generation of reactive oxygen species (ROS) that damage biomolecules such as DNA. These toxic effects were observed in vivo and in vitro. However, the association between esophageal lesions and oxidative stress induced by FB1. Studies in China, Iran and South Africa showed higher exposure to fumonisins in areas with higher risk of esophageal cancer (EC). Exposure to mycotoxins may be inevitable in Mozambique. How mycotoxins, particularly fumonisins from the contaminated food, can be associated with the emergence of EC in Mozambique? Herein, we revise the literature and present some pieces of evidence in order to highlight the burden of mycotoxins and to provide evidence-based considerations for the stakeholders involved in the management of the EC agenda in Mozambique. The information presented herein supports the need to implement novel and/or to revisit the existent detoxification methods to reduce the global burden of mycotoxins and its outcomes in health management.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationPan Afr Med J. 2019 Jul 11;33:187. doi: 10.11604/pamj.2019.33.187.18295. eCollection 2019pt_PT
dc.identifier.doi10.11604/pamj.2019.33.187.18295pt_PT
dc.identifier.issn1937-8688
dc.identifier.urihttp://hdl.handle.net/10400.18/6601
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherAfrican Field Epidemiology Networkpt_PT
dc.relation.publisherversionhttps://www.panafrican-med-journal.com/content/article/33/187/full/pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/pt_PT
dc.subjectAnimalspt_PT
dc.subjectCarcinogens, Environmentalpt_PT
dc.subjectEsophageal Neoplasmspt_PT
dc.subjectFood Contaminationpt_PT
dc.subjectFumonisinspt_PT
dc.subjectFusariumpt_PT
dc.subjectHumanspt_PT
dc.subjectMozambiquept_PT
dc.subjectMycotoxinspt_PT
dc.subjectOxidative Stresspt_PT
dc.subjectReactive Oxygen Speciespt_PT
dc.titleEsophageal cancer in Mozambique: should mycotoxins be a concern?pt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.startPage187pt_PT
oaire.citation.titlePan African Medical Journalpt_PT
oaire.citation.volume33pt_PT
rcaap.embargofctDe acordo com o editor online da revista.pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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