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Bioaccessibility and cytotoxicity of arsenic and mercury in cooked seafood: Implications for food safety and human health risk

2026-05-10Artigo científico Acesso aberto
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dc.contributor.authorVentura, Marta
dc.contributor.authorAssunção, Ricardo
dc.contributor.authorMatos, Beatriz
dc.contributor.authorCoelho, Inês
dc.contributor.authorDelgado, Inês
dc.contributor.authorGueifão, Sandra
dc.contributor.authorSantiago, Susana
dc.contributor.authorCastanheira, Isabel
dc.contributor.authorMartins, Marta
dc.date.accessioned2026-10-01T10:21:21Z
dc.date.available2026-10-01T10:21:21Z
dc.date.issued2026-05-10
dc.description.abstractSeafood is an important component of healthy dietary patterns. However, it can also serve as a dietary source of toxic elements that bioaccumulate in aquatic environments and biomagnify through the food web. This study quantified arsenic (As) and mercury (Hg) in cooked seafood, assessed their bioaccessibility, and evaluated the cytotoxic potential of the bioaccessible fractions using the human intestinal HT-29 cell line. The highest As concentrations were found in bivalves (3.7 ± 0.2 mg kg−1), and the highest Hg concentrations in scabbardfish (0.57 ± 0.01 mg kg−1). The bioaccessibility of As was substantially higher (ranging from 91 ± 2% to 127 ± 6%) than that of Hg (ranging from 4.8 ± 0.3% to 24 ± 8%). The highest bioaccessibility was observed in fresh tuna, 127 ± 6% and 24 ± 8% for As and Hg, respectively. Cytotoxicity assays at 24 h, 48 h, and 72 h indicated that bioaccessible Hg concentrations remained below cytotoxic thresholds. These results highlight the importance of integrating bioaccessibility and toxicological indicators into the evaluation of seafood safety.eng
dc.description.abstractHighlights: Arsenic and mercury exposure were evaluated using an in vitro infogest model; As and Hg were assessed in cooked seafood samples under digestion conditions; Lower bioaccessibility was observed for Hg than for As; The Hg levels in the analysed seafood were below the legislation; HT-29 cells are a key model for assessing dietary toxicity of inorganic contaminants.eng
dc.description.sponsorshipThis work was funded by national funds provided by FCT - Fundação para a Ciência e a Tecnologia, I.P. (Portugal), through the projects UID/4292/2025 (https://doi.org/10.54499/UID/04292/2025) and UID/ PRR/4292/2025 (https://doi.org/10.54499/UID/PRR/04292/2025) granted to MARE - Marine and Environmental Sciences Centre, and the project LA/P/0069/2020 (https://doi.org/10.54499/LA/P/0069/ 2020) granted to the Associate Laboratory ARNET - Aquatic Research Network.
dc.identifier.citationJ Food Compost Anal. 2026 May;155:109229. doi: 10.1016/j.jfca.2026.109229
dc.identifier.doi10.1016/j.jfca.2026.109229
dc.identifier.eid2-s2.0-105039090109
dc.identifier.eissn1096-0481
dc.identifier.issn0889-1575
dc.identifier.urihttp://hdl.handle.net/10400.18/11360
dc.language.isoeng
dc.peerreviewedyes
dc.publisherElsevier
dc.relationAquatic Research Infrastructure Network
dc.relationUID/PRR/4292/2025
dc.relationLA/P/0069/2020
dc.relationUID/04292/2025
dc.relation.hasversionhttps://www.sciencedirect.com/science/article/pii/S0889157526003728?via%3Dihub
dc.relation.ispartofJournal of Food Composition and Analysis
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/
dc.subjectHuman Colon Adenocarcinoma Cell
dc.subjectInorganic Contaminants
dc.subjectIn Vitro Toxicity
dc.subjectSeafood
dc.subjectTotal Diet Study
dc.subjectSegurança Alimentar
dc.titleBioaccessibility and cytotoxicity of arsenic and mercury in cooked seafood: Implications for food safety and human health riskeng
dc.typejournal article
dcterms.referenceshttps://ars.els-cdn.com/content/image/1-s2.0-S0889157526003728-mmc1.docx
dspace.entity.typePublication
oaire.awardNumberLA/P/0069/2020
oaire.awardTitleAquatic Research Infrastructure Network
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0069%2F2020/PT
oaire.citation.startPage109229
oaire.citation.titleJournal of Food Composition and Analysis
oaire.citation.volume155
oaire.fundingStream6817 - DCRRNI ID
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
relation.isProjectOfPublicatione8017e5c-2625-4383-a2c6-935d8aaa0c17
relation.isProjectOfPublication.latestForDiscoverye8017e5c-2625-4383-a2c6-935d8aaa0c17

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