Repository logo
 
Publication

Granulomatous-like immune reaction and hepatic fibrosis induced by Schistosoma haematobium immature worms

2010-05Journal article Open access
Simple item page
dc.contributor.authorBotelho, Mónica C.
dc.contributor.authorOliveira, Paula A.
dc.contributor.authorVieira, Paulo
dc.contributor.authorDelgado, Maria de Lurdes
dc.contributor.authorLourenço, Ligia
dc.contributor.authorLopes, Carlos
dc.contributor.authorMachado, José C .
dc.contributor.authorCosta, José M Correia da
dc.date.accessioned2011-09-19T12:21:52Z
dc.date.available2011-09-19T12:21:52Z
dc.date.issued2010-05
dc.description.abstractGolden hamsters were inoculated with Schistosoma haematobium cercariae to examine histological lesions at different time points over an 18 month period of infection. Hamsters were sacrificed 26 weeks and 82 weeks after inoculation. The parasite was found in the blood and in the liver of infected animals as was expected, but we found exclusively male worms, no female worms nor eggs. Interestingly we observed unexpected hepatic lesions induced by S. haematobium immature male worms alone in the golden hamster, characteristic of schistosome eggs. Samples from liver, kidneys, lungs, bladder and gastrointestinal tract were collected during necropsy to evaluate injuries induced by S. haematobium. Notably we observed hepatitis in the liver of infected hamsters, no lesions were found in other organs. We also found liver fibrosis in infected hamsters. This study provides further experimental evidence for the role that schistosome worms, and their derived antigens, may play in the pathology of the infection and modulation of liver chronic inflammation in the murine model of schistosomiasis.por
dc.identifier.citationVirulence. 2010 May-Jun;1(3):123-9por
dc.identifier.issn2150-5594
dc.identifier.urihttp://hdl.handle.net/10400.18/199
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherLandes Biosciencepor
dc.relation.publisherversionhttp://www.landesbioscience.com/journals/virulence/article/11348/?nocache=1281156688#por
dc.subjectSchistosoma haematobiumpor
dc.subjectAdult wormspor
dc.subjectLiver lesionspor
dc.subjectLiver fibrosispor
dc.subjectInfecções Sistémicas e Zoonosespor
dc.titleGranulomatous-like immune reaction and hepatic fibrosis induced by Schistosoma haematobium immature wormspor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage129por
oaire.citation.startPage123por
oaire.citation.titleVirulencepor
rcaap.rightsopenAccesspor
rcaap.typearticlepor

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Granulomatous-like immune reaction and hepatic fibrosis.pdf
Size:
1.59 MB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

DDI - Artigos em revistas internacionais