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Genotoxicity assessment of silica-coated iron oxide nanoparticles in human astrocytes

2016-06-15Conference object Restricted access
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dc.contributor.authorFernández-Bertólez, Natalia
dc.contributor.authorKiliç, Gözde
dc.contributor.authorCosta, Carla
dc.contributor.authorBrandão, Fátima
dc.contributor.authorFraga, Sónia
dc.contributor.authorTeixeira, João Paulo
dc.contributor.authorPásaro, Eduardo
dc.contributor.authorLaffon, Blanca
dc.contributor.authorValdiglesias, Vanessa
dc.date.accessioned2017-03-09T16:07:49Z
dc.date.available2017-03-09T16:07:49Z
dc.date.issued2016-06-15
dc.description.abstractIron oxide nanoparticles (ION) have great potential for various biomedical and neurobiological applications such as magnetic resonance neuroimaging agents, heating mediators in hyperthermia-based cancer therapy, and molecular cargo in targeted drug/gene delivery across blood-brain barrier. For all these applications, ION must be introduced in the human body and be in contact with cells and tissues, so it is imperative to know the potential risks associated to this exposure, especially in the nervous system. ION surface may be modified by coating with a number of materials to enhance their desirable properties, biocompatibility and biodegradability. Nevertheless, surface covering can alter cellular internalization and other toxicity endpoints. Even though ION seem to be biocompatible and present low toxicity, current data on their effects on the human nervous system are scarce. Thus, the main objective of this work was to examine possible genotoxic effects of ION (silica-coated magnetite) on human glioblastoma (A172) cell line.pt_PT
dc.description.sponsorshipThis work was supported by Xunta de Galicia (EM 2012/079), the project NanoToxClass (ERA ERA-SIINN/001/2013), and TD1204 MODENA COST Action.pt_PT
dc.description.versionN/Apt_PT
dc.identifier.urihttp://hdl.handle.net/10400.18/4585
dc.language.isoengpt_PT
dc.relationEstablishing nanomaterial grouping/ classification strategies according to toxicity and biological effects for supporting risk assessment
dc.subjectNanotoxicologypt_PT
dc.subjectNanoparticlespt_PT
dc.subjectIron Oxide Nanoparticlespt_PT
dc.subjectGenotoxicitypt_PT
dc.subjectGenotoxicidade Ambientalpt_PT
dc.titleGenotoxicity assessment of silica-coated iron oxide nanoparticles in human astrocytespt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.awardTitleEstablishing nanomaterial grouping/ classification strategies according to toxicity and biological effects for supporting risk assessment
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/ERA-SIINN%2F0001%2F2013/PT
oaire.citation.conferencePlaceBarcelona, Espanhapt_PT
oaire.citation.titleXXII Congreso de la Sociedad Española de Mutagénesis Ambiental (SEMA), 13-15 Junio 2016pt_PT
oaire.fundingStream3599-PPCDT
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsclosedAccesspt_PT
rcaap.typeconferenceObjectpt_PT
relation.isProjectOfPublicationa118e28a-71df-4d9f-b18c-9d4e164baf22
relation.isProjectOfPublication.latestForDiscoverya118e28a-71df-4d9f-b18c-9d4e164baf22

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