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Prevalence of microcephaly in Europe: population based study

2016-09-13Journal article Open access
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dc.contributor.authorMorris, Joan K.
dc.contributor.authorRankin, Judith
dc.contributor.authorGarne, Ester
dc.contributor.authorLoane, Maria
dc.contributor.authorGreenlees, Ruth
dc.contributor.authorAddor, Marie-Claude
dc.contributor.authorArriola, Larraitz
dc.contributor.authorBarisic, Ingeborg
dc.contributor.authorBergman, Jorieke E.H.
dc.contributor.authorCsaky-Szunyogh, Melinda
dc.contributor.authorDias, Carlos Matias
dc.contributor.authorDraper, Elizabeth S.
dc.contributor.authorGatt, Miriam
dc.contributor.authorKhoshnood, Babak
dc.contributor.authorKlungsoyr, Kari
dc.contributor.authorKurinczuk, Jennifer J.
dc.contributor.authorLynch, Catherine
dc.contributor.authorMcDonnell, Robert
dc.contributor.authorNelen, Vera
dc.contributor.authorNeville, Amanda J.
dc.contributor.authorO'Mahony, Mary T.
dc.contributor.authorPierini, Anna
dc.contributor.authorRandrianaivo, Hanitra
dc.contributor.authorRissmann, Anke
dc.contributor.authorTucker, David
dc.contributor.authorVerellen-Dumoulin, Christine
dc.contributor.authorde Walle, Hermien E.K.
dc.contributor.authorWellesley, Diana
dc.contributor.authorWiesel, Awi
dc.contributor.authorDolk, Helen
dc.date.accessioned2017-03-03T17:40:47Z
dc.date.available2017-03-03T17:40:47Z
dc.date.issued2016-09-13
dc.descriptionCo-autor: Carlos Matias Dias - Departamento de Epidemiologia, Instituto Nacional de Saúde Doutor Ricardo Jorgept_PT
dc.descriptionFree PMC Article: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5021822/pt_PT
dc.description.abstractObjectives: To provide contemporary estimates of the prevalence of microcephaly in Europe, determine if the diagnosis of microcephaly is consistent across Europe, and evaluate whether changes in prevalence would be detected using the current European surveillance performed by EUROCAT (the European Surveillance of Congenital Anomalies). Design: Questionnaire and population based observational study. Setting: 24 EUROCAT registries covering 570 000 births annually in 15 countries. Participants: Cases of microcephaly not associated with a genetic condition among live births, fetal deaths from 20 weeks’ gestation, and terminations of pregnancy for fetal anomaly at any gestation. Main: outcome measures Prevalence of microcephaly (1 Jan 2003-31 Dec 2012) analysed with random effects Poisson regression models to account for heterogeneity across registries. Results: 16 registries responded to the questionnaire, of which 44% (7/16) used the EUROCAT definition of microcephaly (a reduction in the size of the brain with a skull circumference more than 3 SD below the mean for sex, age, and ethnic origin), 19% (3/16) used a 2 SD cut off, 31% (5/16) were reliant on the criteria used by individual clinicians, and one changed criteria between 2003 and 2012. Prevalence of microcephaly in Europe was 1.53 (95% confidence interval 1.16 to 1.96) per 10 000 births, with registries varying from 0.4 (0.2 to 0.7) to 4.3 (3.6 to 5.0) per 10 000 (χ2=338, df=23, I2=93%). Registries with a 3 SD cut off reported a prevalence of 1.74 per 10 000 (0.86 to 2.93) compared with those with the less stringent 2 SD cut off of 1.21 per 10 000 (0.21 to 2.93). The prevalence of microcephaly would need to increase in one year by over 35% in Europe or by over 300% in a single registry to reach statistical significance (P<0.01). Conclusions: EUROCAT could detect increases in the prevalence of microcephaly from the Zika virus of a similar magnitude to those observed in Brazil. Because of the rarity of microcephaly and discrepant diagnostic criteria, however, the smaller increases expected in Europe would probably not be detected. Clear diagnostic criteria for microcephaly must be adopted across Europe.pt_PT
dc.description.sponsorshipThis study was funded by the European Union in the framework of the Health Programme (2008-13).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationBMJ. 2016 Sep 13;354:i4721. doi: 10.1136/bmj.i4721pt_PT
dc.identifier.doi10.1136/bmj.i4721pt_PT
dc.identifier.issn0959-8138
dc.identifier.urihttp://hdl.handle.net/10400.18/4464
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherBMJ Publishing Grouppt_PT
dc.relation.publisherversionhttp://www.bmj.com/content/354/bmj.i4721pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/pt_PT
dc.subjectMicrocefaliapt_PT
dc.subjectEstados de Saúde e de Doençapt_PT
dc.subjectObservação em Saúde e Vigilânciapt_PT
dc.subjectRENACpt_PT
dc.subjectEUROCATpt_PT
dc.subjectEuropean Surveillance of Congenital Anomaliespt_PT
dc.subjectEuropean Surveillancept_PT
dc.subjectCongenital Anomaliespt_PT
dc.subjectEuropept_PT
dc.titlePrevalence of microcephaly in Europe: population based studypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.startPagei4721pt_PT
oaire.citation.titleBMJpt_PT
oaire.citation.volume354pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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