Publication
Neuron and Glial Cells Exposed to Cerium Dioxide Nanoparticles: Results from MTT and γH2AX Assays
| dc.contributor.author | Fernández-Bertólez, Natalia | |
| dc.contributor.author | Touzani, Assia | |
| dc.contributor.author | Martínez, Luisa | |
| dc.contributor.author | Méndez, Josefina | |
| dc.contributor.author | Reis, Ana Teresa | |
| dc.contributor.author | Costa, Carla | |
| dc.contributor.author | Fraga, Sonia | |
| dc.contributor.author | Teixeira, João Paulo | |
| dc.contributor.author | Pásaro, Eduardo | |
| dc.contributor.author | Laffon, Blanca | |
| dc.contributor.author | Valdiglesias, Vanessa | |
| dc.date.accessioned | 2024-02-05T16:06:25Z | |
| dc.date.available | 2024-02-05T16:06:25Z | |
| dc.date.issued | 2023-05-05 | |
| dc.description | This article belongs to the Proceedings of The 4th International Online Conference on Nanomaterials publicado em: Mater Proc. 2023;14(1):4. https://www.mdpi.com/2673-4605/14/1/4 | pt_PT |
| dc.description | Proceeding Paper | pt_PT |
| dc.description.abstract | Cerium dioxide nanoparticles (CeO2NP) show antioxidant enzyme-like properties and reactive oxygen species (ROS) scavenging activity, making them a promising material for potential therapeutic applications in neurodegenerative diseases. The objective of this work was to assess the biological behavior of CeO2NP in human SH-SY5Y neuronal and A172 glial cells by means of the MTT assay and the γH2AX assay. Despite the significant dose- and time-dependent NP internalization by both cell lines, nanoceria generally presented scarce cytotoxicity or genotoxicity, essentially restricted to the highest NP doses and longest exposure times. In conclusion, a high biocompatibility of CeO2NP was observed under the conditions tested. | pt_PT |
| dc.description.sponsorship | This research was funded by the Spanish Ministry of Science and Innovation MCIN/AEI/10.13039/501100011033, grant PID2020-114908GA-I00; Xunta de Galicia (ED431B 2022/16); CICA-Disrupting Project (2021SEM-B2); the Spanish Ministry of Education, Culture and Sport (BEAGAL18/00142 to V.V.); and the Portuguese Fundação para a Ciência e a Tecnologia (FCT) (SFRH/BPD/122112/2016 to A.T.R). | pt_PT |
| dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
| dc.identifier.uri | http://hdl.handle.net/10400.18/9037 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.relation | A novelty study on the human uptake, genotoxicity and immunotoxicity of nanoparticles and legacy contaminants mixtures | |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt_PT |
| dc.subject | Cerium Dioxide Nanoparticles | pt_PT |
| dc.subject | CeO2NP | pt_PT |
| dc.subject | Nanomaterials | pt_PT |
| dc.subject | Cytotoxicity | pt_PT |
| dc.subject | Genotoxicity | pt_PT |
| dc.subject | Cellular Uptake | pt_PT |
| dc.subject | Neurotoxicity | pt_PT |
| dc.subject | Nanoceria Biocompatibility | pt_PT |
| dc.subject | Nanomedicine | pt_PT |
| dc.subject | Genotoxicidade Ambiental | pt_PT |
| dc.title | Neuron and Glial Cells Exposed to Cerium Dioxide Nanoparticles: Results from MTT and γH2AX Assays | pt_PT |
| dc.type | conference object | |
| dspace.entity.type | Publication | |
| oaire.awardTitle | A novelty study on the human uptake, genotoxicity and immunotoxicity of nanoparticles and legacy contaminants mixtures | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT//SFRH%2FBPD%2F122112%2F2016/PT | |
| oaire.citation.conferencePlace | Online | pt_PT |
| oaire.citation.title | 4th International Online Conference on Nanomaterials, 5–19 May 2023 | pt_PT |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| rcaap.embargofct | Acesso de acordo com política editorial da revista. | pt_PT |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | conferenceObject | pt_PT |
| relation.isProjectOfPublication | dbbc9b73-85f0-4bba-b64e-3624dc6b4d90 | |
| relation.isProjectOfPublication.latestForDiscovery | dbbc9b73-85f0-4bba-b64e-3624dc6b4d90 |