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Impact of iodine supplementation during preconception, pregnancy and lactation on maternal thyroid homeostasis and offspring psychomotor development: protocol of the IodineMinho prospective study

2020-11-13Journal article Open access
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dc.contributor.authorLopes-Pereira, Maria
dc.contributor.authorRoque, Susana
dc.contributor.authorCosta, Patrício
dc.contributor.authorQuialheiro, Anna
dc.contributor.authorSantos, Nadine Correia
dc.contributor.authorGoios, Ana
dc.contributor.authorVilarinho, Laura
dc.contributor.authorCorreia-Neves, Margarida
dc.contributor.authorPalha, Joana Almeida
dc.date.accessioned2021-04-07T16:09:00Z
dc.date.available2021-04-07T16:09:00Z
dc.date.issued2020-11-13
dc.description.abstractBackground: Iodine deficiency is the most common cause of preventable brain harm and cognitive impairment in children. Portuguese women of childbearing age, pregnant women and their progeny were shown to have inadequate iodine intake. Consequently, the Portuguese Health Authorities have recommended a daily supplementation with 150-200 µg iodine in preconception, pregnancy, and lactation. The IodineMinho study intends to evaluate whether (i) this recommendation impacted on the prevalence of iodine deficiency in pregnant women from the Minho region of Portugal, (ii) the time of initiation of iodine supplementation (if any) influences the serum levels of thyroid hormones at several intervals during pregnancy and (iii) there are serum thyroid-hormone parameters in the 1st trimester of pregnancy that predict psychomotor development of the child at 18 months of age. Methods: Most Portuguese women are followed throughout pregnancy in community Family Health Units, where family physicians may choose to follow the National recommendation or other, concerning iodine sufficiency. This study will recruit women (N = 304) who intend to become pregnant or are already pregnant from 10 representative Units. Physician's approach and prescriptions, sociodemographic, nutrition and clinical information will be obtained at baseline and throughout pregnancy. To evaluate endocrine function, blood and urine samples will be collected at recruitment, once in each trimester of pregnancy, at delivery and 3 months after delivery. Breastmilk samples will be collected for iodine and energy content analysis. Children will be evaluated for psychomotor development at 18 months. Maternal thyroid volume will be evaluated by ultrasound scan at baseline, in the 3rd trimester and at 3 months after delivery. Discussion: Iodine deficiency early during development precludes children from achieving full intellectual capabilities. This protocol describes a study that is innovative and unique in its detailed and comprehensive evaluation of maternal and child endocrine and psychomotor parameters. By evaluating the effectiveness of the iodine supplementation recommendation, it will contribute to the public health systems' efforts to provide excellence in maternal and infant care. Trial registration: ClinicalTrials.gov, NCT04288531 . Registered 28 February 2020-Retrospectively registered.pt_PT
dc.description.sponsorshipSpecific funding for this study is pending. The launching phase of this study was supported by National funds, through the Foundation for Science and Technology (FCT) - project UIDB/50026/2020 and UIDP/50026/2020; by the projects NORTE-01-0145-FEDER-000013, NORTE-01-0145-FEDER-000023 and NORTE-01-0246-FEDER-000012, supported by Norte Portugal Regional Operational Program (NORTE 2020), under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (ERDF).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationBMC Pregnancy Childbirth. 2020 Nov 13;20(1):693. doi: 10.1186/s12884-020-03376-y.pt_PT
dc.identifier.doi10.1186/s12884-020-03376-ypt_PT
dc.identifier.issn1471-2393
dc.identifier.urihttp://hdl.handle.net/10400.18/7658
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherBMCpt_PT
dc.relationUIDP/50026/202pt_PT
dc.relationLA - ICVS/3B's - Associate Laboratory
dc.relation.publisherversionhttps://bmcpregnancychildbirth.biomedcentral.com/articles/10.1186/s12884-020-03376-ypt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectChild Healthpt_PT
dc.subjectIodinept_PT
dc.subjectIodine Deficiencypt_PT
dc.subjectIodine Supplementationpt_PT
dc.subjectMaternal Healthpt_PT
dc.subjectNutrition; Pregnancypt_PT
dc.subjectPsychomotor Developmentpt_PT
dc.subjectPublic Health Interventionpt_PT
dc.subjectDoenças Genéticaspt_PT
dc.titleImpact of iodine supplementation during preconception, pregnancy and lactation on maternal thyroid homeostasis and offspring psychomotor development: protocol of the IodineMinho prospective studypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleLA - ICVS/3B's - Associate Laboratory
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F50026%2F2020/PT
oaire.citation.issue1pt_PT
oaire.citation.startPage693pt_PT
oaire.citation.titleBMC Pregnancy and Childbirthpt_PT
oaire.citation.volume20pt_PT
oaire.fundingStream6817 - DCRRNI ID
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.embargofctAcesso de acordo com política editorial da revista.pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isProjectOfPublication4b09703b-1d57-4d95-9cdf-9a36a2886c9d
relation.isProjectOfPublication.latestForDiscovery4b09703b-1d57-4d95-9cdf-9a36a2886c9d

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