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Exposure assessment of total DON in urine of Portuguese adult population under the HBM4EU aligned studies

2022-09-18Conference object Open access
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dc.contributor.authorAlvito, P.C.
dc.contributor.authorSilva, M.J.
dc.contributor.authorViegas, S.
dc.contributor.authorVasco, E.
dc.contributor.authorMartins, C.
dc.contributor.authorAssunção, R.
dc.contributor.authorSilva, S.
dc.contributor.authorGilles, L.
dc.contributor.authorGovarts, E.
dc.contributor.authorSchoeters, G.
dc.contributor.authorNamorado, S.
dc.date.accessioned2023-02-09T11:20:24Z
dc.date.available2023-02-09T11:20:24Z
dc.date.issued2022-09-18
dc.descriptionP-22 | Risk prediction and assessmentpt_PT
dc.description.abstractMycotoxins are secondary metabolites of fungi that can be found in food commodities. Exposure to mycotoxins has been associated with several adverse health effects, including hepatotoxicity. nephrotoxicity, immunotoxicity, mutagenicity and carcinogenicity.As such, from a public health perspective it is important to monitor and to assess the risk associated to mycotoxins’ exposure. In the scope of the European Human Biomonitoring Initiative (HBM4EU), exposure to mycotoxins, namely to deoxynivalenol (DON) was analysed in adults from several European countries, including Portugal. Data was collected under the project “Exposure of the Portuguese Population to Environmental Chemicals: a study nested in INSEF 2015”. INSEF-ExpoQuim, was an epidemiological study nested in the first Portuguese Health Examination Survey (INSEF), that enrolled individuals aged 28–39 years, living in Portugal for more than 12 months and able to follow an interview in Portuguese. Fieldwork was developed between May 2019 and March 2020 and first morning urine samples were collected along with data on socio-demographic characteristics, living conditions and residential history, habits/ lifestyle, nutrition, health, occupation and substance specific information covering nearly all exposure pathways. Procedures followed the guidelines of HBM4EU. Total DON (sum of free DON + DONglucuronides after deconjugation) was determined in 295 urine samples by a qualified laboratory and using a harmonized analytical method. Results: showed that the Portuguese population was exposed to DON (mean = 9.8 mg/L; 95% CI: 8.7–10.9 mg/L). DON concentrations were significantly higher for samples collected in spring and summer. Individuals living in rural areas and with a lower education levels presented higher exposures to DON, as well as individuals with a higher bread consumption frequency (≥4 times per week). No differences were found regarding sex, age, occupation, income or consumption of other foods. Comparing this study’s data with the human biomonitoring guidance value (HBM-GV) determined for DON in the scope of HBM4EU (Total DON: 0.69 μg DON/kg bw/total 24 h ≈ 23 μg DON/L urine) 12.5% of the participants presented values above the HBM-GV. Overall, the results from this study showed that the Portuguese population is currently exposed to DON, with a significant proportion of individuals presenting exposures to values that warrant further assessment, including a close monitoring of exposure in the future and the development and implementation of policy measures aimed at minimizing exposure and improving the health of the population.pt_PT
dc.description.sponsorshipThis work was conducted under the HBM4EU project and was funded by the European Union’s Horizon 2020 research and innovation program under grant agreement no. 733032. Thanks are also due to FCT/MCTES through national funds, to CESAM (UIDP/ 50017/2020+UIDB/50017/2020).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationToxicol Lett. 2022 Sep;368(Suppl 1):S281. doi: 10.1016/j.toxlet.2022.07.741pt_PT
dc.identifier.doi10.1016/j.toxlet.2022.07.741pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.18/8517
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationEuropean Human Biomonitoring Initiative
dc.relationCentre for Environmental and Marine Studies
dc.relationCentre for Environmental and Marine Studies
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/abs/pii/S037842742201668X?via%3Dihubpt_PT
dc.subjectMycotoxinspt_PT
dc.subjectHBM4EU Aligned Studiespt_PT
dc.subjectMicotoxinaspt_PT
dc.subjectToxicologiapt_PT
dc.subjectAvaliaçao do Riscopt_PT
dc.subjectDeterminantes da Saúde e da Doençapt_PT
dc.subjectPortugalpt_PT
dc.titleExposure assessment of total DON in urine of Portuguese adult population under the HBM4EU aligned studiespt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.awardTitleEuropean Human Biomonitoring Initiative
oaire.awardTitleCentre for Environmental and Marine Studies
oaire.awardTitleCentre for Environmental and Marine Studies
oaire.awardURIinfo:eu-repo/grantAgreement/EC/H2020/733032/EU
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F50017%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F50017%2F2020/PT
oaire.citation.conferencePlaceMaastricht, The Netherlandspt_PT
oaire.citation.startPageS281pt_PT
oaire.citation.titleXVIth International Congress of Toxicology “Uniting in Toxicology”, UTOX/EUROTOX 18-22 September 2022​pt_PT
oaire.citation.volume368pt_PT
oaire.fundingStreamH2020
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameEuropean Commission
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typeconferenceObjectpt_PT
relation.isProjectOfPublication6815dc2d-ef7e-4535-8dd3-5193c8bffba5
relation.isProjectOfPublication4e22de31-8fc5-4b15-b980-3fd0edf5515d
relation.isProjectOfPublication0e72e6c8-b610-43e0-931c-8ad275ad6093
relation.isProjectOfPublication.latestForDiscovery6815dc2d-ef7e-4535-8dd3-5193c8bffba5

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