Can human biomonitoring studies contribute to improve public health decisions?

Silva, Maria João; Louro, Henriqueta

Publication

Can human biomonitoring studies contribute to improve public health decisions?

2017-06-23Conference object

dc.contributor.author	Silva, Maria João
dc.contributor.author	Louro, Henriqueta
dc.date.accessioned	2018-02-12T15:22:21Z
dc.date.available	2018-02-12T15:22:21Z
dc.date.issued	2017-06-23
dc.description	Abstract publicado em: J Clin Toxicol 2017, 7:3 (suppl)., 66. Doi: 10.4172/2161-0495-C1-025-005: Disponível em: https://www.omicsonline.org/conference-proceedings/2161-0495-C1-025-005.pdf	pt_PT
dc.description.abstract	Statement of the Problem: Our previous work has shown the presence of the hazardous chemicals within a complex mixture of contaminants (e.g., metals, pesticides, polycyclic aromatic hydrocarbons) trapped in sediments of a Portuguese estuary. In that case-study, an epidemiological survey confirmed the exposure of the local population mainly through food chain, suggesting the need of a biomonitoring study that includes the quantification of contaminants in biological fluids as well as biomarkers of early biological effects (e.g., biochemical, genetic and omics-based endpoints) in the target population. Recognizing the knowledge gap between exposure to hazardous substances and health outcomes, not only in Portuguese population, but also throughout Europe, the project European Human Biomonitoring Initiative (HBM4EU) has just started, with the overarching goal of generating knowledge towards the safe management of chemicals. Methodology & Theoretical Orientation: Human biomonitoring will be used to understand the human exposure to chemicals and resulting health impacts. The first steps rely on harmonizing procedures for human biomonitoring across countries, to provide policy makers with comparable data on human internal exposure to chemicals and mixtures of chemicals at EU level. Then, linking data on internal exposure with the hazardous chemicals, will allow to aggregate external exposure and identifying exposure pathways and upstream sources. Conclusion & Significance: By generating scientific evidence on the causal links between human exposure to chemicals and negative health outcomes, an evidence-base will be established to allow the use of human biomonitoring in chemical risk assessment methodologies to data. The risk management and communication with stakeholders and policy makers will ensure that results are applied in the design of new regulations for chemicals and for supporting public health protection policies.	pt_PT
dc.description.sponsorship	HBM4EU project, Grant agreement No: 733032	pt_PT
dc.description.version	info:eu-repo/semantics/publishedVersion	pt_PT
dc.identifier.uri	http://hdl.handle.net/10400.18/4943
dc.language.iso	eng	pt_PT
dc.peerreviewed	yes	pt_PT
dc.relation	European Human Biomonitoring Initiative
dc.subject	Genotoxicidade Ambiental	pt_PT
dc.subject	Risk Assessment	pt_PT
dc.subject	Public Health	pt_PT
dc.subject	Human Biomonitoring	pt_PT
dc.subject	Chemical Risks	pt_PT
dc.title	Can human biomonitoring studies contribute to improve public health decisions?	pt_PT
dc.type	conference object
dspace.entity.type	Publication
oaire.awardTitle	European Human Biomonitoring Initiative
oaire.awardURI	info:eu-repo/grantAgreement/EC/H2020/733032/EU
oaire.citation.conferencePlace	Paris, França	pt_PT
oaire.citation.title	9th Euro-Global Summit on Toxicology and Applied Pharmacology, 22-24 Junho 2017	pt_PT
oaire.fundingStream	H2020
project.funder.identifier	http://doi.org/10.13039/501100008530
project.funder.name	European Commission
rcaap.rights	restrictedAccess	pt_PT
rcaap.type	conferenceObject	pt_PT
relation.isProjectOfPublication	6815dc2d-ef7e-4535-8dd3-5193c8bffba5
relation.isProjectOfPublication.latestForDiscovery	6815dc2d-ef7e-4535-8dd3-5193c8bffba5