Publication
Applications of iPSCs in Gaucher Disease
| dc.contributor.author | Amaral, Olga | |
| dc.contributor.author | duarte, ana | |
| dc.contributor.author | Ribeiro, Diogo | |
| dc.contributor.author | Santos, Renato | |
| dc.contributor.author | Bragança, José | |
| dc.date.accessioned | 2021-04-21T17:13:39Z | |
| dc.date.available | 2021-04-21T17:13:39Z | |
| dc.date.issued | 2020-05-25 | |
| dc.description.abstract | In recent years, human induced pluripotent cell (hiPSC) models have slowly become a trend in experimental modelling of disease, following and complementing animal based models. Human iPSCs provide an innovative manner for modelling Gaucher Disease (GD). Since 2008 several groups have created iPSCs models from GD patients, with various genotypes, and differentiated iPSCs to neural precursors and macrophages among many other types of cells. hiPSC models have been developed from multiple GD donors, recapitulating the disease phenotypic hallmarks. These models have provided a new platform for pathophysiology studies and for the testing of small molecules with therapeutic goals. | pt_PT |
| dc.description.sponsorship | FCT-MCTES projects PTDC/BIM-MEC/4762/2014 (OA), UIDB/00211/2020 (ICETA), PTDC/BTM-TEC/28044/2017 (JB). INSARJ (MS). | pt_PT |
| dc.description.version | N/A | pt_PT |
| dc.identifier.uri | http://hdl.handle.net/10400.18/7689 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.relation.publisherversion | https://www.ewggd2020.com/ | pt_PT |
| dc.subject | Gaucher Disease | pt_PT |
| dc.subject | iPSCs | pt_PT |
| dc.subject | Human Genetics | pt_PT |
| dc.subject | Doenças Genéticas | pt_PT |
| dc.title | Applications of iPSCs in Gaucher Disease | pt_PT |
| dc.type | conference object | |
| dspace.entity.type | Publication | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FBIM-MEC%2F4762%2F2014/PT | |
| oaire.citation.conferencePlace | (online) | pt_PT |
| oaire.citation.title | EWGGD Virtual Scientific Meeting, 25 May 2020 | pt_PT |
| oaire.fundingStream | 3599-PPCDT | |
| person.familyName | Amaral | |
| person.givenName | Olga | |
| person.identifier.ciencia-id | 6F1F-54A3-BBB9 | |
| person.identifier.orcid | 0000-0002-3478-2122 | |
| person.identifier.scopus-author-id | 7004054964 | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| rcaap.rights | closedAccess | pt_PT |
| rcaap.type | conferenceObject | pt_PT |
| relation.isAuthorOfPublication | 8c7fb04a-80c0-4dd7-b3c5-682f6d25662b | |
| relation.isAuthorOfPublication.latestForDiscovery | 8c7fb04a-80c0-4dd7-b3c5-682f6d25662b | |
| relation.isProjectOfPublication | 9452b84c-9691-47bb-82ba-75ed40cdfa04 | |
| relation.isProjectOfPublication.latestForDiscovery | 9452b84c-9691-47bb-82ba-75ed40cdfa04 |
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