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Impact of physical exercise training on DNA damage and repair: does gender play a role?

2016-06-21Conference object Restricted access
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dc.contributor.authorSilva, Ana Inês
dc.contributor.authorSoares, J.P.
dc.contributor.authorSilva, A.M.
dc.contributor.authorGaivão, I.
dc.contributor.authorMota, M.P.
dc.contributor.authorMatos, M.
dc.date.accessioned2017-03-09T13:19:56Z
dc.date.available2017-03-09T13:19:56Z
dc.date.issued2016-06-21
dc.description.abstractAcute physical exercise is associated with an enhanced aerobic metabolism, which can result in an increased formation of reactive oxygen species (ROS). ROS can react with DNA, causing strand breaks and modified bases, namely 8-oxoguanine, one of the most common products of oxidative DNA damage, which is repaired by 8-oxoguanine DNA glycosylase 1 (OGG1). Regular physical exercise is considered as a key component of a healthy lifestyle, and its preventive effect, at least in part, is due to oxidative stress induced adaptation, which has been related with an increase in antioxidant activity and in oxidative damage repair enzymes. Gender-related differences concerning DNA damage and DNA repair have been reported. Therefore, the main purpose of this study was to analyse the effects of 16 weeks of combined physical exercise training on DNA damage and repair, in 26 healthy Caucasian individuals, 14 males and 12 females.pt_PT
dc.description.sponsorshipFCT for the research grant SFRH/BD/66438/2009. The project PTDC/DES/121575/2010, and also UID/AGR/04033/2013.pt_PT
dc.description.versionN/Apt_PT
dc.identifier.urihttp://hdl.handle.net/10400.18/4574
dc.language.isoporpt_PT
dc.relationPhysical exercise role on Human` lymphocyte DNA damage reduction: possible influence of oxidative stress and DNA repair capacity
dc.subjectPhysical Exercisept_PT
dc.subjectDNA Damagept_PT
dc.subjectGenotoxicidade Ambientalpt_PT
dc.titleImpact of physical exercise training on DNA damage and repair: does gender play a role?pt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.awardTitlePhysical exercise role on Human` lymphocyte DNA damage reduction: possible influence of oxidative stress and DNA repair capacity
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876-PPCDTI/PTDC%2FDES%2F121575%2F2010/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FAGR%2F04033%2F2013/PT
oaire.citation.conferencePlacePorto, Portugalpt_PT
oaire.citation.title3rd International Conference on Occupational & Environmental Toxicology, 21-23 June 2016pt_PT
oaire.fundingStream5876-PPCDTI
oaire.fundingStream5876
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsclosedAccesspt_PT
rcaap.typeconferenceObjectpt_PT
relation.isProjectOfPublication1b035030-e8a7-423c-8071-c4124e68c2e7
relation.isProjectOfPublication2854d17f-1c22-46c6-a66d-f03b7bbd0011
relation.isProjectOfPublication.latestForDiscovery2854d17f-1c22-46c6-a66d-f03b7bbd0011

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