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Patient-reported outcomes in tuberculosis: a qualitative exploration of psychosocial, economic, and treatment-related challenges

2025-10-27Artigo científico Acesso aberto
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dc.contributor.authorViegas, Pedro
dc.contributor.authorFerreira, Luís L.
dc.contributor.authorVieira, Mariana
dc.contributor.authorBarbosa, Pedro
dc.contributor.authorRamos, João P.
dc.contributor.authorDuarte, Raquel
dc.date.accessioned2026-02-12T12:17:35Z
dc.date.available2026-02-12T12:17:35Z
dc.date.issued2025-10-27
dc.description.abstractObjective: Personal experiences, perceptions, and views of patients are crucial in understanding the subjective impacts of diseases. The complexity and duration of tuberculosis treatment impose significant physical, emotional, social, and economic burdens, highlighting the need for person-centered, integrated care strategies that address stigma, fatigue, and accessibility to support well-being. Patient-reported outcomes (PROs) are essential for capturing patient perspectives and improving health care strategies. In this study we explored the multifaceted experiences of patients with tuberculosis, seeking to understand their values and priorities during treatment. Methods:Semistructured interviews with adult tuberculosis patients were conducted at a referral center for tuberculosis diagnosis and management in northern Portugal. After verbatim transcription and anonymization, thematic analysis was performed. Results: Seventeen interviews were conducted. Most (58.8%) of the study participants were male, and most had pulmonary tuberculosis. Our thematic analysis identified five PROs: treatment experiences; health-related quality of life; functional status; symptoms and symptom burden; and health behaviors. People with tuberculosis acknowledged the impact of multiple factors on their overall health, particularly the psychological and physical burdens of tuberculosis and its treatment. Several areas for improvement and opportunities for enhanced support were identified, particularly in communication, emotional support, and management of treatment burden. Conclusions: Our findings highlight the need for tailored PRO measures (PROMs) addressing treatment burden, psychosocial distress, and functional limitations in tuberculosis care. Enhancing communication, psychological support, and multidisciplinary approaches in tuberculosis management could improve patient outcomes and overall well-being. Addressing tuberculosis-related stigma and providing targeted interventions may contribute to a more people-centered approach to care.eng
dc.description.sponsorshipThis study received financial support from the Foundation for Science and Technology (Grant nos. UIDB/04750/2020 [DOI: https://doi.org/10.54499/UIDB/04750/2020] and LA/P/0064/2020 [DOI: https://doi.org/10.54499/LA/P/0064/2020]). João P Ramos and Mariana Vieira are recipients of doctoral grants from the Foundation for Science and Technology and the Fundo Social Europeu Mais (FSE, European Social Fund Plus; Grant nos. 2024.00492.BD [JPR] and 2024.03947.BD [MV]).
dc.identifier.citationJ Bras Pneumol. 2025 Oct 27;51(4):e20250159. doi: 10.36416/1806-3756/e20250159. eCollection 2025
dc.identifier.doi10.36416/1806-3756/e20250159
dc.identifier.eissn1806-3756
dc.identifier.pmid41172415
dc.identifier.urihttp://hdl.handle.net/10400.18/10916
dc.language.isoeng
dc.peerreviewedyes
dc.publisherSociedade Brasileira de Pneumologia e Tisiologia
dc.relationEpidemiology Research Unit - Institute of Public Health, University of Porto
dc.relationLaboratory for Integrative and Translational Research in Population Health
dc.relation2024.00492.BD
dc.relation2024.03947.BD
dc.relation.hasversionhttps://jornaldepneumologia.com.br/details/4145/en-US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectTuberculosis
dc.subjectPatient Reported Outcome Measures
dc.subjectQualitative Research
dc.subjectQuality of Life
dc.subjectInfecções Respiratórias
dc.subjectCuidados de Saúde
dc.titlePatient-reported outcomes in tuberculosis: a qualitative exploration of psychosocial, economic, and treatment-related challengeseng
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleEpidemiology Research Unit - Institute of Public Health, University of Porto
oaire.awardTitleLaboratory for Integrative and Translational Research in Population Health
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04750%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0064%2F2020/PT
oaire.citation.issue4
oaire.citation.startPagee20250159
oaire.citation.titleJornal Brasileiro de Pneumologia
oaire.citation.volume51
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
relation.isProjectOfPublication05f4f337-eeba-4c07-82ed-4202b21618a2
relation.isProjectOfPublication18ca3cb0-ef66-4dd8-b45e-4cb0654cd7e8
relation.isProjectOfPublication.latestForDiscovery05f4f337-eeba-4c07-82ed-4202b21618a2

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