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Expression Profile of Circulating miRNAs in Autism Spectrum Disorders Population sample

2014-11Conference object Restricted access
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dc.contributor.authorConceição, I.C.
dc.contributor.authorRodrigues, A.C.
dc.contributor.authorKwiatkowska, K.
dc.contributor.authorPicanço, I.
dc.contributor.authorCafé, C.
dc.contributor.authorAlmeida, J.
dc.contributor.authorMouga, S.
dc.contributor.authorEnguita, F.J.
dc.contributor.authorOliveira, G.
dc.contributor.authorVicente, A.M.
dc.date.accessioned2014-11-26T17:42:48Z
dc.date.available2014-11-26T17:42:48Z
dc.date.issued2014-11
dc.description.abstractAutism Spectrum Disorder (ASD) is a common complex disorder, highly heterogeneous and with unclear etiology. While many different rare variants are known to be etiological factors for ASD, they don’t completely explain the genetic variance in this disorder, and common genetic variants could not, thus far, be identified. The possible contribution of epigenetic factors, such as deregulated miRNAs expression, should be addressed. miRNAs are small noncoding RNA molecules that negatively regulate gene expression via degradation or translational repression of their target messenger RNAs. miRNAs play critical roles in several biological processes, and are associated with human pathology. Recent studies have suggested that miRNAs in plasma and serum might be derived from circulating blood cells under healthy conditions, but might be released from pathological tissues during illness. The strong correlation between circulating and tissue miRNAs indicates that circulating miRNAs might be biomarkers for diseases, including central nervous system disorders. We are currently assessing miRNA profiles in plasma from ASD patients and patients with other neurodevelopmental disabilities (eg. psychomotor developmental delay, intellectual disability, etc).por
dc.identifier.urihttp://hdl.handle.net/10400.18/2470
dc.language.isoengpor
dc.publisherInstituto Nacional de Saúde Doutor Ricardo Jorge, IPpor
dc.subjectPerturbações do Desenvolvimento Infantil e Saúde Mentalpor
dc.subjectAutism Spectrum Disorderspor
dc.subjectAutismpor
dc.subjectSaúde Públicapor
dc.titleExpression Profile of Circulating miRNAs in Autism Spectrum Disorders Population samplepor
dc.typeconference object
dspace.entity.typePublication
oaire.citation.conferencePlaceLisboa, Portugalpor
oaire.citation.title18ª Reunião Anual da Sociedade Portuguesa de Genética Humana, 19-21 Novembro 2014por
rcaap.rightsembargoedAccesspor
rcaap.typeconferenceObjectpor

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