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Individual common variants exert weak effects on the risk for autism spectrum disorderspi

2012-08-08Journal article Open access
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dc.contributor.authorAnney, R.
dc.contributor.authorKlei, L.
dc.contributor.authorPinto, D.
dc.contributor.authorAlmeida, J.
dc.contributor.authorBacchelli, E.
dc.contributor.authorBaird, G.
dc.contributor.authorBolshakova, N.
dc.contributor.authorBölte, S.
dc.contributor.authorBolton, P.F.
dc.contributor.authorBourgeron, T.
dc.contributor.authorBrennan, S.
dc.contributor.authorBrian, J.
dc.contributor.authorCasey, J.
dc.contributor.authorConroy, J.
dc.contributor.authorCorreia, C.
dc.contributor.authorCorsello, C.
dc.contributor.authorCrawford, E.L.
dc.contributor.authorde Jonge, M.
dc.contributor.authorDelorme, R.
dc.contributor.authorDuketis, E.
dc.contributor.authorDuque, F.
dc.contributor.authorEstes, A.
dc.contributor.authorFarrar, P.
dc.contributor.authorFernandez, B.A.
dc.contributor.authorFolstein, S.E.
dc.contributor.authorFombonne, E.
dc.contributor.authorGilbert, J.
dc.contributor.authorGillberg, C.
dc.contributor.authorGlessner, J.T.
dc.contributor.authorGreen, A.
dc.contributor.authorGreen, J.
dc.contributor.authorGuter, S.J.
dc.contributor.authorHeron, E.A.
dc.contributor.authorHolt, R.
dc.contributor.authorHowe, J.L.
dc.contributor.authorHughes, G.
dc.contributor.authorHus, V.
dc.contributor.authorIgliozzi, R.
dc.contributor.authorJacob, S.
dc.contributor.authorKenny, G.P.
dc.contributor.authorKim, C.
dc.contributor.authorKolevzon, A.
dc.contributor.authorKustanovich, V.
dc.contributor.authorLajonchere, C.M.
dc.contributor.authorLamb, J.A.
dc.contributor.authorLaw-Smith, M.
dc.contributor.authorLeboyer, M.
dc.contributor.authorLe Couteur, A.
dc.contributor.authorLeventhal, B.L.
dc.contributor.authorLiu, X.Q.
dc.contributor.authorLombard, F.
dc.contributor.authorLord, C.
dc.contributor.authorLotspeich, L.
dc.contributor.authorLund, S.C.
dc.contributor.authorMagalhaes, T.R.
dc.contributor.authorMantoulan, C.
dc.contributor.authorMcDougle, C.J.
dc.contributor.authorMelhem, N.M.
dc.contributor.authorMerikangas, A.
dc.contributor.authorMinshew, N.J.
dc.contributor.authorMirza, G.K.
dc.contributor.authorMunson, J.
dc.contributor.authorNoakes, C.
dc.contributor.authorNygren, G.
dc.contributor.authorPapanikolaou, K.
dc.contributor.authorPagnamenta, A.T.
dc.contributor.authorParrini, B.
dc.contributor.authorPaton, T.
dc.contributor.authorPickles, A.
dc.contributor.authorPosey, D.J.
dc.contributor.authorPoustka, F.
dc.contributor.authorRagoussis, J.
dc.contributor.authorRegan, R.
dc.contributor.authorRoberts, W.
dc.contributor.authorRoeder, K.
dc.contributor.authorRoge, B.
dc.contributor.authorRutter, M.L.
dc.contributor.authorSchlitt, S.
dc.contributor.authorShah, N.
dc.contributor.authorSheffield, V.C.
dc.contributor.authorSoorya, L.
dc.contributor.authorSousa, I.
dc.contributor.authorStoppioni, V.
dc.contributor.authorSykes, N.
dc.contributor.authorTancredi, R.
dc.contributor.authorThompson, A.P.
dc.contributor.authorThomson, S.
dc.contributor.authorTryfon, A.
dc.contributor.authorTsiantis, J.
dc.contributor.authorVan Engeland, H.
dc.contributor.authorVincent, J.B.
dc.contributor.authorVolkmar, F.
dc.contributor.authorVorstman, J.
dc.contributor.authorWallace, S.
dc.contributor.authorWing, K.
dc.contributor.authorWittemeyer, K.
dc.contributor.authorWood, S.
dc.contributor.authorZurawiecki, D.
dc.contributor.authorZwaigenbaum, L.
dc.contributor.authorBailey, AJ
dc.contributor.authorBattaglia, A.
dc.contributor.authorCantor, R.M.
dc.contributor.authorCoon, H.
dc.contributor.authorCuccaro, M.L.
dc.contributor.authorDawson, G.
dc.contributor.authorEnnis, S.
dc.contributor.authorFreitag, C.M.
dc.contributor.authorGeschwind, D.H.
dc.contributor.authorHaines, J.L.
dc.contributor.authorKlauck, S.M.
dc.contributor.authorMcMahon, W.M.
dc.contributor.authorMaestrini, E.
dc.contributor.authorMiller, J.
dc.contributor.authorMonaco, A.P.
dc.contributor.authorNelson, S.F.
dc.contributor.authorNurnberger Jr, J.I.
dc.contributor.authorOliveira, G.
dc.contributor.authorParr, J.R.
dc.contributor.authorPericak-Vance, M.A.
dc.contributor.authorPiven, J.
dc.contributor.authorSchellenberg, G.D.
dc.contributor.authorScherer, S.W.
dc.contributor.authorVicente, A.M.
dc.contributor.authorWassink, T.H.
dc.contributor.authorWijsman, E.M.
dc.contributor.authorBetancur, C.
dc.contributor.authorBuxbaum, J.D.
dc.contributor.authorCook, E.H.
dc.contributor.authorGallagher, L.
dc.contributor.authorGill, M.
dc.contributor.authorHallmayer, J.
dc.contributor.authorPaterson, A.D.
dc.contributor.authorSutcliffe, J.S.
dc.contributor.authorSzatmari, P.
dc.contributor.authorVieland, V.J.
dc.contributor.authorHakonarson, H.
dc.contributor.authorDevlin, B.
dc.date.accessioned2012-09-17T15:49:13Z
dc.date.available2012-09-17T15:49:13Z
dc.date.issued2012-08-08
dc.description.abstractWhile it is apparent that rare variation can play an important role in the genetic architecture of autism spectrum disorders (ASDs), the contribution of common variation to the risk of developing ASD is less clear. To produce a more comprehensive picture, we report Stage 2 of the Autism Genome Project genome-wide association study, adding 1301 ASD families and bringing the total to 2705 families analysed (Stages 1 and 2). In addition to evaluating the association of individual single nucleotide polymorphisms (SNPs), we also sought evidence that common variants, en masse, might affect the risk. Despite genotyping over a million SNPs covering the genome, no single SNP shows significant association with ASD or selected phenotypes at a genome-wide level. The SNP that achieves the smallest P-value from secondary analyses is rs1718101. It falls in CNTNAP2, a gene previously implicated in susceptibility for ASD. This SNP also shows modest association with age of word/phrase acquisition in ASD subjects, of interest because features of language development are also associated with other variation in CNTNAP2. In contrast, allele scores derived from the transmission of common alleles to Stage 1 cases significantly predict case status in the independent Stage 2 sample. Despite being significant, the variance explained by these allele scores was small (Vm< 1%). Based on results from individual SNPs and their en masse effect on risk, as inferred from the allele score results, it is reasonable to conclude that common variants affect the risk for ASD but their individual effects are modest.por
dc.identifier.citationHum Mol Genet. 2012 Aug 8. [Epub ahead of print]por
dc.identifier.issn1460-2083
dc.identifier.otherdoi:10.1093/hmg/dds301
dc.identifier.urihttp://hdl.handle.net/10400.18/1003
dc.language.isoengpor
dc.publisherOxford University Presspor
dc.relation.publisherversionhttp://hmg.oxfordjournals.org/content/early/2012/08/08/hmg.dds301.longpor
dc.subjectPerturbações do Desenvolvimento Infantil e Saúde Mentalpor
dc.titleIndividual common variants exert weak effects on the risk for autism spectrum disorderspipor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.titleHuman Molecular Geneticspor
rcaap.rightsopenAccesspor
rcaap.typearticlepor

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