Publication
Molecular features underlying the higher ecological success of C. trachomatis E and F genotypes
| dc.contributor.author | Nunes, A. | |
| dc.contributor.author | Ferreira, R. | |
| dc.contributor.author | Borges, V. | |
| dc.contributor.author | Borrego, M.J. | |
| dc.contributor.author | Gomes, João Paulo | |
| dc.date.accessioned | 2012-02-24T18:19:22Z | |
| dc.date.available | 2012-02-24T18:19:22Z | |
| dc.date.issued | 2011-03 | |
| dc.description.abstract | In the light of the >98% genomic similarity among Chlamydia trachomatis serovars, the higher worldwide ecological success of E and F is enigmatic. We intend to provide a quick overview of the molecular data that distinguish these from the remaining strains. Examples are: - E and F possess a similar chromosomal genetic make-up distinct from the remaining genotypes. Some loci linked to this independent co-segregation comprehend membrane proteins, hypothetical virulence factors, and regulatory regions (published data). - Some loci reveal nonrandom mutational patterns, where mutations exclusive of E and F are clustered in specific protein domains, likely promoting strains functional and/or structural attributes (published data). - Based on data from a worldwide survey, MOMP of E and F exhibit the lowest mutation rate (22.3-fold lower), implying more fitted antigenic profiles to deal with host immunity (published data). - The likelihood of E and F strains to undergo genetic recombination is about 12-fold lower than that of the other genotypes (P<10-2), suggesting a putative clonal evolution, where superimposed favorable clones may be strongly maintained in vivo (preliminary data from our lab). - Strains E and F do not seem to originate higher infectious load in vivo, when compared with other genital genotypes (published data). Full-genomic data from multiple and diverse clinical isolates will be essential to decipher the secret behind the higher ecological success of E and F strains. | por |
| dc.identifier.uri | http://hdl.handle.net/10400.18/637 | |
| dc.language.iso | eng | por |
| dc.publisher | Instituto Nacional de Saúde Doutor Ricardo Jorge, IP | por |
| dc.subject | Infecções Sexualmente Transmissíveis | por |
| dc.subject | Chlamydia Trachomatis | por |
| dc.subject | Ecological Sucess | por |
| dc.title | Molecular features underlying the higher ecological success of C. trachomatis E and F genotypes | por |
| dc.type | conference object | |
| dspace.entity.type | Publication | |
| oaire.citation.conferencePlace | Redondo Beach, California - EUA | por |
| oaire.citation.title | 5th Biennial Meeting of the Chlamydia Basic Research Society (CBRS), 18 March 2011 | por |
| rcaap.rights | openAccess | por |
| rcaap.type | conferenceObject | por |