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Umrah- and travel-associated meningococcal disease due to multiple serogroup W ST-11 sub-strains pre-Hajj 2024

2025-07-21Artigo científico Acesso aberto
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datacite.subject.fosCiências Médicas::Ciências da Saúde
dc.contributor.authorLucidarme, Jay
dc.contributor.authorDeghmane, Ala-Eddine
dc.contributor.authorSharma, Shalabh
dc.contributor.authorMeilleur, Courtney
dc.contributor.authorEriksson, Lorraine
dc.contributor.authorMölling, Paula
dc.contributor.authorClaus, Heike
dc.contributor.authorvan Sorge, Nina
dc.contributor.authorBettencourt, Célia
dc.contributor.authorBajanca-Lavado, Paula
dc.contributor.authorTsang, Raymond S.W.
dc.contributor.authorCaugant, Dominique A.
dc.contributor.authorStefanelli, Paola
dc.contributor.authorNeri, Arianna
dc.contributor.authorTzanakaki, Georgina
dc.contributor.authorLekshmi, Aiswarya
dc.contributor.authorCampbell, Helen
dc.contributor.authorClark, Stephen A.
dc.contributor.authorHeymer, Emma J.
dc.contributor.authorRibeiro, Sonia
dc.contributor.authorWillerton, Laura
dc.contributor.authorWalsh, Lloyd
dc.contributor.authorBai, Xilian
dc.contributor.authorLâm, Thiên-Trí
dc.contributor.authorWagle, Basanta R.
dc.contributor.authorWalia, Vishakh
dc.contributor.authorHowie, Rebecca L.
dc.contributor.authorNeatherlin, John
dc.contributor.authorRubis, Amy
dc.contributor.authorVachon, Madhura
dc.contributor.authorMcNamara, Lucy A.
dc.contributor.authorLadhani, Shamez N.
dc.contributor.authorTaha, Muhamed-Kheir
dc.contributor.authorBorrow, Ray
dc.date.accessioned2026-02-10T09:31:02Z
dc.date.available2026-02-10T09:31:02Z
dc.date.issued2025-07-21
dc.description.abstractObjectives: Collectively, the Hajj and Umrah pilgrimages draw > 30 million pilgrims to the Kingdom of Saudi Arabia (KSA) each year. Before Hajj 2024 (14 to 19 June), the meningococcal serogroup W ST-11 complex (W:cc11) Hajj-strain sublineage caused multiple international cases of invasive meningococcal disease (IMD) associated with travel to the Middle East and Asia. Here we identify and characterise the strains responsible. Methods: All Hajj strain sublineage genomes on PubMLST.org underwent core genome MLST comparisons (PubMLST.org). Results: Isolates from 30 cases, across seven countries, formed five phylogenetic clusters within two distinct strains. Travel histories included KSA, other Middle Eastern countries, India, Mauritius, Kenya via Turkey, and no known associated travel. The prevalent strain, representing four clusters, had no African, and limited Middle Eastern, representation. The geo-temporal distribution of available genomes indicated Eastern Europe as a possible source. Conclusions: The rapid expansion of Umrah/travel-related W:cc11 IMD cases in early 2024 was due to multiple strains/sublineages. Despite the involvement of non-KSA travel-destinations, the coincidence of cases with the busy month of Ramadan, and the abrupt cessation during Hajj (when vaccine compliance is maximal), suggest that Umrah was a key driver and highlight the need to reinforce mandatory vaccination whilst maintaining global vigilance.eng
dc.description.abstractHighlights: -International travel-related meningococcal W disease cases occurred pre-Hajj 2024. -Genomic analyses identified five clusters due to distinct ST-11 complex sub-strains.-One sub-strain was of African heritage. -Four sub-strains belonged to a novel strain of possible Eastern European heritage. -Enforcement of vaccination of all pilgrims will help control international spread.eng
dc.identifier.citationJ Infect. 2025 Oct;91(4):106558. doi: 10.1016/j.jinf.2025.106558. Epub 2025 Jul 21
dc.identifier.doi10.1016/j.jinf.2025.106558
dc.identifier.eissn1532-2742
dc.identifier.issn0163-4453
dc.identifier.pmid40701332
dc.identifier.urihttp://hdl.handle.net/10400.18/10873
dc.language.isoeng
dc.peerreviewedyes
dc.publisherElsevier
dc.relation.hasversionhttps://www.sciencedirect.com/science/article/pii/S0163445325001525?via%3Dihub
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectMeningococcal Serogroup W
dc.subjectST-11 Clonal Complex
dc.subjectHajj Strain Sublineage
dc.subjectOutbreak
dc.subjectUmrah
dc.subjectHajj
dc.titleUmrah- and travel-associated meningococcal disease due to multiple serogroup W ST-11 sub-strains pre-Hajj 2024eng
dc.typejournal article
dcterms.referenceshttps://ars.els-cdn.com/content/image/1-s2.0-S0163445325001525-mmc1.docx
dcterms.referenceshttps://ars.els-cdn.com/content/image/1-s2.0-S0163445325001525-mmc2.xlsx
dspace.entity.typePublication
oaire.citation.issue4
oaire.citation.startPage106558
oaire.citation.titleJournal of Infection
oaire.citation.volume91
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85

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