An insight into the transcriptome of Rhipicephalus bursa: differential gene expression upon feeding and in response to salivary glands infection with Babesia ovis

Couto, J.; Antunes, S.; Ferrolho, J.; Santos, A.S.; Santos-Silva, M.M.; de la Fuente, J.; Domingos, A.

http://hdl.handle.net/10400.18/4690

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Understanding the paradigm of the pathogen-tick-host triad remains an intricate issue. Basic research focusing on each one of these interplays is necessary to better comprehend this dynamic system. One of such complex association is the Babesia ovis, transmitted by the Rhipicephalus bursa ticks. B. ovis is an intra-erythrocytic protozoan parasite highly pathogenic parasite, causing severe infection in sheep. Pathogen and vector co-evolved and during infection a substantial molecular dialogue/interchanges takes place. The pathogen is adapted to both its hosts, and remarkably transovarial and transstadial transmissions are present in the vector. In ticks, the salivary glands (SG) play important role in both, feeding and pathogen interaction, being a vehicle for pathogen transmission and a barrier that they need to surpass.