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Metabolic Dysfunction and Asthma: Current Perspectives

2020-07-27Journal article Open access
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dc.contributor.authorPite, Helena
dc.contributor.authorAguiar, Laura
dc.contributor.authorMorello, Judit
dc.contributor.authorMonteiro, Emilia
dc.contributor.authorAlves, Ana Catarina
dc.contributor.authorBourbon, Mafalda
dc.contributor.authorMorais-Almeida, Mário
dc.date.accessioned2021-03-05T16:14:10Z
dc.date.available2021-03-05T16:14:10Z
dc.date.issued2020-07-27
dc.descriptionReviewpt_PT
dc.description.abstractThe increasing knowledge of the mechanisms involved in metabolism is shifting the paradigms by which the pathophysiology of many pulmonary diseases is understood. Metabolic dysfunction is recognized in obesity-associated asthma, but other metabolic conditions have been shown to be independently related to asthma. Novel insights have also recently been brought by metabolomics in this filed. The purpose of this review is to discuss current perspectives regarding metabolic dysfunction in asthma, from obesity-related asthma to other metabolic conditions and the role of current pharmacological therapeutic strategies and lifestyle interventions. Obesity is a well-recognized risk factor for asthma across the lifespan, which is generally associated with poorer response to current available treatments, rendering a more severe, refractory disease status. Besides the epidemiological and clinical link, untargeted metabolomics studies have recently supported the obesity-associated asthma phenotype at the molecular level. Not only obesity-related, but also other aspects of metabolic dysregulation can be independently linked to asthma. These include hyperinsulinemia, dyslipidemia and hypertension, which need to be taken into account, even in the non-obese patient. Untargeted metabolomics studies have further highlighted several other metabolic pathways that can be altered in asthma, namely regarding oxidative stress and systemic inflammation, and also suggesting the importance of microbiota in asthma pathogenesis. Considering the reduced response to corticosteroids, other pharmacologic treatments have been shown to be effective regardless of body mass index. Non-pharmacologic treatments (namely weight reduction and dietary changes) may bring substantial benefit to the asthmatic patient. Taken together, this evidence points towards the need to improve our knowledge in this filed and, in particular, to address the influence of environmental factors in metabolic dysfunction and asthma development. Personalized medicine is definitely needed to optimize treatment, including a holistic view of the asthmatic patient in order to set accurate pharmacologic therapy together with dietary, physical exercise and lifestyle interventions.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationJ Asthma Allergy. 2020 Jul 27;13:237-247. doi: 10.2147/JAA.S208823. eCollection 2020.pt_PT
dc.identifier.doi10.2147/JAA.S208823pt_PT
dc.identifier.issn1178-6965
dc.identifier.urihttp://hdl.handle.net/10400.18/7338
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherDove Medical Presspt_PT
dc.relation.publisherversionhttps://www.dovepress.com/metabolic-dysfunction-and-asthma-current-perspectives-peer-reviewed-article-JAApt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAsthmapt_PT
dc.subjectDietpt_PT
dc.subjectInflammationpt_PT
dc.subjectMetabolicpt_PT
dc.subjectMetabolomicspt_PT
dc.subjectObesitypt_PT
dc.subjectDoenças Cardio e Cérebro-vascularespt_PT
dc.titleMetabolic Dysfunction and Asthma: Current Perspectivespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage247pt_PT
oaire.citation.startPage237pt_PT
oaire.citation.titleJournal of Asthma and Allergypt_PT
oaire.citation.volume13pt_PT
rcaap.embargofctAcesso de acordo com página web do editor da revista.pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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