Publication
Outbreak of acute respiratory infection among infants in Lisbon, Portugal, caused by human adenovirus serotype 3 and a new 7/3 recombinant strain
| dc.contributor.author | Andrade, Helena Rebelo de | |
| dc.contributor.author | Pereira, Cristiana | |
| dc.contributor.author | Gíria, Marta | |
| dc.contributor.author | Prudêncio, Ema | |
| dc.contributor.author | Brito, Maria João | |
| dc.contributor.author | Calé, Etelvina | |
| dc.contributor.author | Taveira, Nuno | |
| dc.date.accessioned | 2011-09-19T12:40:42Z | |
| dc.date.available | 2011-09-19T12:40:42Z | |
| dc.date.issued | 2010-04 | |
| dc.description.abstract | Human adenoviruses (AdVs) typically cause mild illnesses in otherwise healthy hosts. We investigated a pediatric outbreak of acute respiratory infection with fatal outcomes that occurred in Lisbon, Portugal, in 2004. Biological specimens were collected from 83 children attending two nurseries, a kinesiotherapy clinic, and the household of a nanny. Adenovirus infection was confirmed in 48 children by PCR and virus isolation. Most (96%) isolates were classified as being of subspecies B1. Phylogenetic analysis of fiber and hexon gene sequences revealed that most infants were infected with AdV serotype 3 (AdV3) strains. Infants attending one nursery harbored a new recombinant strain containing an AdV serotype 7 hexon and serotype 3 fiber (AdV7/3). Both the AdV3 and the AdV7/3 strains caused fatal infections. Two different serotype 3 strains were circulating in Lisbon in 2004, and the new AdV7/3 recombinant type originated from only one of those strains. These results demonstrate that recombination leads to the emergence of new adenovirus strains with epidemic and lethal potential. | por |
| dc.identifier.citation | J Clin Microbiol. 2010 Apr;48(4):1391-6. Epub 2010 Feb 10 | por |
| dc.identifier.issn | 0095-1137 | |
| dc.identifier.other | doi:10.1128/JCM.02019-09 | |
| dc.identifier.uri | http://hdl.handle.net/10400.18/208 | |
| dc.language.iso | eng | por |
| dc.peerreviewed | yes | por |
| dc.publisher | American Society for Microbiology. | por |
| dc.relation.publisherversion | http://jcm.asm.org/cgi/content/full/48/4/1391?view=long&pmid=20147640 | por |
| dc.subject | Resistência aos Antimicrobianos | por |
| dc.subject | Adenovirus | por |
| dc.title | Outbreak of acute respiratory infection among infants in Lisbon, Portugal, caused by human adenovirus serotype 3 and a new 7/3 recombinant strain | por |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.endPage | 1396 | por |
| oaire.citation.startPage | 1391 | por |
| oaire.citation.title | Journal of Clinical Microbiology | por |
| rcaap.rights | openAccess | por |
| rcaap.type | article | por |
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