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Mycobacterium tuberculosis lineage 4 comprises globally distributed and geographically restricted sublineages

2016-10-31Journal article Restricted access
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dc.contributor.authorStucki, David
dc.contributor.authorBrites, Daniela
dc.contributor.authorJeljeli, Leïla
dc.contributor.authorCoscolla, Mireia
dc.contributor.authorLiu, Qingyun
dc.contributor.authorTrauner, Andrej
dc.contributor.authorFenner, Lukas
dc.contributor.authorRutaihwa, Liliana
dc.contributor.authorBorrell, Sonia
dc.contributor.authorLuo, Tao
dc.contributor.authorGao, Qian
dc.contributor.authorKato-Maeda, Midori
dc.contributor.authorBallif, Marie
dc.contributor.authorEgger, Matthias
dc.contributor.authorMacedo, Rita
dc.contributor.authorMardassi, Helmi
dc.contributor.authorMoreno, Milagros
dc.contributor.authorVilanova, Griselda Tudo
dc.contributor.authorFyfe, Janet
dc.contributor.authorGloban, Maria
dc.contributor.authorThomas, Jackson
dc.contributor.authorJamieson, Frances
dc.contributor.authorGuthrie, Jennifer L.
dc.contributor.authorAsante-Poku, Adwoa
dc.contributor.authorYeboah-Manu, Dorothy
dc.contributor.authorWampande, Eddie
dc.contributor.authorSsengooba, Willy
dc.contributor.authorJoloba, Moses
dc.contributor.authorBoom, W. Henry
dc.contributor.authorBasu, Indira
dc.contributor.authorBower, James
dc.contributor.authorSaraiva, Margarida
dc.contributor.authorVasconcellos, Sidra E.G.
dc.contributor.authorSuffys, Philip
dc.contributor.authorKoch, Anastasia
dc.contributor.authorWilkinson, Robert
dc.contributor.authorGail-Bekker, Linda
dc.contributor.authorMalla, Bijaya
dc.contributor.authorLey, Serej D.
dc.contributor.authorBeck, Hans-Peter
dc.contributor.authorde Jong, Bouke C.
dc.contributor.authorToit, Kadri
dc.contributor.authorSanchez-Padilla, Elisabeth
dc.contributor.authorBonnet, Maryline
dc.contributor.authorGil-Brusola, Ana
dc.contributor.authorFrank, Matthias
dc.contributor.authorPenlap Beng, Veronique N.
dc.contributor.authorEisenach, Kathleen
dc.contributor.authorAlani, Issam
dc.contributor.authorNdung'u, Perpetual Wangui
dc.contributor.authorRevathi, Gunturu
dc.contributor.authorGehre, Florian
dc.contributor.authorAkter, Suriya
dc.contributor.authorNtoumi, Francine
dc.contributor.authorStewart-Isherwood, Lynsey
dc.contributor.authorNtinginya, Nyanda E.
dc.contributor.authorRachow, Andrea
dc.contributor.authorHoelscher, Michael
dc.contributor.authorCirillo, Daniela Maria
dc.contributor.authorSkenders, Girts
dc.contributor.authorHoffner, Sven
dc.contributor.authorBakonyte, Daiva
dc.contributor.authorStakenas, Petras
dc.contributor.authorDiel, Roland
dc.contributor.authorCrudu, Valeriu
dc.contributor.authorMoldovan, Olga
dc.contributor.authorAl-Hajoj, Sahal
dc.contributor.authorOtero, Larissa
dc.contributor.authorBarletta, Francesca
dc.contributor.authorCarter, E. Jane
dc.contributor.authorDiero, Lameck
dc.contributor.authorSupply, Philip
dc.contributor.authorComas, Iñaki
dc.contributor.authorNiemann, Stefan
dc.contributor.authorGagneux, Sebastien
dc.date.accessioned2022-02-09T15:20:00Z
dc.date.available2022-02-09T15:20:00Z
dc.date.issued2016-10-31
dc.descriptionRita Macedo - INSApt_PT
dc.description.abstractGeneralist and specialist species differ in the breadth of their ecological niches. Little is known about the niche width of obligate human pathogens. Here we analyzed a global collection of Mycobacterium tuberculosis lineage 4 clinical isolates, the most geographically widespread cause of human tuberculosis. We show that lineage 4 comprises globally distributed and geographically restricted sublineages, suggesting a distinction between generalists and specialists. Population genomic analyses showed that, whereas the majority of human T cell epitopes were conserved in all sublineages, the proportion of variable epitopes was higher in generalists. Our data further support a European origin for the most common generalist sublineage. Hence, the global success of lineage 4 reflects distinct strategies adopted by different sublineages and the influence of human migration.pt_PT
dc.description.sponsorshipThis work was supported by the Swiss National Science Foundation (grants 310030_166687 (S.G.) and 320030_153442 (M.E.), Swiss HIV Cohort Study grant 740 (L.F.)), the European Research Council (309540-EVODRTB, S.G.), TB-PAN-NET (FP7-223681, S.N.), PathoNgenTrace (FP7- 278864-2, S.N.) projects, SystemsX.ch (S.G.), the German Center for Infection Research (DZIF, S.N.), the Novartis Foundation (S.G.), and the Natural Science Foundation of China (91631301, Q.G.).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationNat Genet. 2016 Dec;48(12):1535-1543. doi: 10.1038/ng.3704. Epub 2016 Oct 31pt_PT
dc.identifier.doi10.1038/ng.3704pt_PT
dc.identifier.issn1061-4036
dc.identifier.urihttp://hdl.handle.net/10400.18/7943
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherNature Researchpt_PT
dc.relationNext Generation Genome Based High Resolution Tracing of Pathogens
dc.relation.publisherversionhttps://www.nature.com/articles/ng.3704pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectDNA, Bacterialpt_PT
dc.subjectGenomicspt_PT
dc.subjectGenotypept_PT
dc.subjectGlobal Healthpt_PT
dc.subjectHumanspt_PT
dc.subjectMycobacterium tuberculosispt_PT
dc.subjectPhylogeographypt_PT
dc.subjectPolymorphism, Geneticpt_PT
dc.subjectTuberculosispt_PT
dc.subjectInfecções Respiratóriaspt_PT
dc.titleMycobacterium tuberculosis lineage 4 comprises globally distributed and geographically restricted sublineagespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleNext Generation Genome Based High Resolution Tracing of Pathogens
oaire.awardURIinfo:eu-repo/grantAgreement/EC/FP7/278864/EU
oaire.citation.endPage1543pt_PT
oaire.citation.issue12pt_PT
oaire.citation.startPage1535pt_PT
oaire.citation.titleNature Geneticspt_PT
oaire.citation.volume48pt_PT
oaire.fundingStreamFP7
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.nameEuropean Commission
rcaap.embargofctAcesso de acordo com política editorial da revista.pt_PT
rcaap.rightsembargoedAccesspt_PT
rcaap.typearticlept_PT
relation.isProjectOfPublicatione6c55173-abbb-42c3-8a29-1867c2ac29a3
relation.isProjectOfPublication.latestForDiscoverye6c55173-abbb-42c3-8a29-1867c2ac29a3

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