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UPF1 internal ribosome entry site-mediated translation and its importance in tumorigenesis
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Orientador(es)
Resumo(s)
Aims: UPF1 internal ribosome entry site-mediated translation and its importance in tumorigenesis; Confirm UPF1 5’ untranslated region (UTR) can mediate
internal ribosome entry site (IRES)-mediated translation; Check whether the IRES-dependent translation is maintained under cap-dependent-impairing conditions
(hypoxia); Identify the minimal sequence required for IRES-mediated translation; Investigate the biological role of UPF1 IRES-mediated
translation in tumorigenesis.
Descrição
Palavras-chave
Nonsense-mediated mRNA Decay Up-frameshift 1 UPF1 Genómica Funcional Genómica Funcional e Estrutural Doenças Genéticas