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HBM4EU diisocyanates study – results from a collaborative European human biological monitoring study on occupational exposure

2023-06-21Conference object Restricted access
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dc.contributor.authorJones, Kate
dc.contributor.authorGalea, K.S.
dc.contributor.authorScholten, B.
dc.contributor.authorLoikala, M.
dc.contributor.authorPorras, S.P.
dc.contributor.authorBousoumah, R.
dc.contributor.authorNdaw, S.
dc.contributor.authorLeese, E.
dc.contributor.authorLouro, Henriqueta
dc.contributor.authorSilva, Maria João
dc.contributor.authorViegas, S.
dc.contributor.authorGodderis, L.
dc.contributor.authorVerdonck, J.
dc.contributor.authorPoels, K.
dc.contributor.authorGӧen, T.
dc.contributor.authorDuca, R.C.
dc.contributor.authorSantonen, T.
dc.contributor.authorHBM4EU diisocyanates study team
dc.date.accessioned2024-02-06T14:28:33Z
dc.date.available2024-02-06T14:28:33Z
dc.date.issued2023-06-21
dc.description.abstractDiisocyanates have long been a leading cause of occupational asthma in Europe, and they are now restricted under the REACH regulation. As part of the European Human Biomonitoring project (HBM4EU), we conducted an occupational exposure survey on diisocyanates in five European countries. 116 workers were recruited across four job categories: (1) Use of diisocyanates-based glues, adhesives or sealants; (2) Polyurethane coating of large surfaces; (3) Spray application of urethane foam; (4) Spray coating of vehicles. Fifty controls (within the same companies) were also recruited. The study collected urine samples (analysed for diisocyanate-derived diamines and lysine conjugates), blood samples (analysed for diisocyanate-specific antibodies, inflammatory markers, and diisocyanate-specific haemoglobin adducts), buccal cells (micronucleus analysis) and measured fractional exhaled nitric oxide (FeNO). In addition, occupational hygiene measurements (air monitoring and skin wipe samples) and questionnaires were collected. Initial results showed significant airborne exposures for some tasks (spraying polyurethane foam insulation), with elevated urinary diamine levels compared to controls (p<0.001), and detection of the specific MDI-lysine conjugate. Most workers did not show increased FeNO, but some individuals had elevated results (controls max 30 ppb (n=49), workers max 161 ppb (n=108). Further ongoing data analysis will be presented.pt_PT
dc.description.sponsorshipThis work has received external funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No. 733032 and received co-funding from the author’s organizations and/or Ministries. The full HBM4EU diisocyanates study team has previously been acknowledged in the study protocol (https://doi.org/10.3390/ijerph19148811).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.urihttp://hdl.handle.net/10400.18/9047
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationEuropean Human Biomonitoring Initiative
dc.subjectDiisocyanatespt_PT
dc.subjectOccupational Asthmapt_PT
dc.subjectOccupational Exposurept_PT
dc.subjectEuropept_PT
dc.subjectEnvironmental Genotoxicitypt_PT
dc.subjectGenotoxicidade Ambientalpt_PT
dc.titleHBM4EU diisocyanates study – results from a collaborative European human biological monitoring study on occupational exposurept_PT
dc.typeconference object
dspace.entity.typePublication
oaire.awardTitleEuropean Human Biomonitoring Initiative
oaire.awardURIinfo:eu-repo/grantAgreement/EC/H2020/733032/EU
oaire.citation.conferencePlacePorto, Portugalpt_PT
oaire.citation.title12th International Symposium on Biological Monitoring in Occupational and Environmental Health (ISBM-12), 21-23 June 2023pt_PT
oaire.fundingStreamH2020
person.familyNameLouro
person.familyNameSilva
person.givenNameHenriqueta
person.givenNameMaria Joao
person.identifier157627
person.identifier.ciencia-id721D-2BB1-7DB1
person.identifier.ciencia-id7710-643D-97A3
person.identifier.orcid0000-0001-9744-7332
person.identifier.orcid0000-0002-6060-0716
person.identifier.scopus-author-id6507971479
person.identifier.scopus-author-id55944437600
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.nameEuropean Commission
rcaap.rightsrestrictedAccesspt_PT
rcaap.typeconferenceObjectpt_PT
relation.isAuthorOfPublication2361a951-8b9a-4b90-92d6-f6384003a242
relation.isAuthorOfPublicationa7763685-7c34-468d-b958-9dd0aca66db4
relation.isAuthorOfPublication.latestForDiscovery2361a951-8b9a-4b90-92d6-f6384003a242
relation.isProjectOfPublication6815dc2d-ef7e-4535-8dd3-5193c8bffba5
relation.isProjectOfPublication.latestForDiscovery6815dc2d-ef7e-4535-8dd3-5193c8bffba5

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