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Environmental exposure to toxicants mixtures from a multi-purpose estuary: perspectives for a biomonitoring study in Portugal

2016-04-17Conference object Restricted access
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dc.contributor.authorSilva, Maria João
dc.contributor.authorPinto, Miguel
dc.contributor.authorCosta, Pedro M.
dc.contributor.authorLouro, Henriqueta
dc.contributor.authorCastanheira, Isabel
dc.contributor.authorMachado, Ausenda
dc.contributor.authorDias, Carlos
dc.contributor.authorFernandes, Ana Paula
dc.contributor.authorMartinho, AP
dc.contributor.authorCosta, MH
dc.contributor.authorCaeiro, Sandra
dc.contributor.authorLavinha, Joao
dc.date.accessioned2016-05-24T15:59:17Z
dc.date.available2016-05-24T15:59:17Z
dc.date.issued2016-04-17
dc.description.abstractThis work was focused on a multi-purpose estuarine environment (river Sado estuary, SW Portugal) around which a number of activities (e.g., fishing, farming, heavy industry, tourism and recreational activities) coexist with urban centres with a total of about 200 000 inhabitants. Based on previous knowledge of the hazardous chemicals within the ecosystem and their potential toxicity to benthic species, this project intended to evaluate the impact of estuarine contaminants on the human and ecosystem health. An integrative methodology based on epidemiological, analytical and biological data and comprising several lines of evidence, namely, human contamination pathways, human health effects, consumption of local produce, estuarine sediments, wells and soils contamination, effects on commercial benthic organisms, and genotoxic potential of sediments, was used. The epidemiological survey confirmed the occurrence of direct and indirect (through food chain) exposure of the local population to estuarine contaminants. Furthermore, the complex mixture of contaminants (e.g., metals, pesticides, polycyclic aromatic hydrocarbons) trapped in the estuary sediments was toxic to human liver cells exposed in vitro, causing cell death, oxidative stress and genotoxic effects that might constitute a risk factor for the development of chronic-degenerative diseases, on the long term. Finally, the integration of data from several endpoints indicated that the estuary is moderately impacted by toxicants that affect also the aquatic biota. Nevertheless, the human health risk can only be correctly assessed through a biomonitoring study including the quantification of contaminants (or metabolites) in biological fluids as well as biomarkers of early biological effects (e.g., biochemical, genetic and omics-based endpoints) and genetic susceptibility in the target population. Data should be supported by a detailed survey to assess the impact of the contaminated seafood and local farm products consumption on human health and, particularly, on metabolic diseases or cancer development.pt_PT
dc.description.sponsorshipWork supported by the Portuguese Foundation for Science and Technology (PTDC/SAU-ESA/100107/2008).pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.18/3814
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.subjectGenotoxicidade Ambientalpt_PT
dc.subjectEnvironmental Genotoxicitypt_PT
dc.subjectSado River Estuarypt_PT
dc.subjectHuman Health Risk Assessmentpt_PT
dc.subjectBiomonitoringpt_PT
dc.subjectHazardous Chemicalspt_PT
dc.titleEnvironmental exposure to toxicants mixtures from a multi-purpose estuary: perspectives for a biomonitoring study in Portugalpt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876-PPCDTI/PTDC%2FSAU-ESA%2F100107%2F2008/PT
oaire.citation.conferencePlaceBerlim, Alemanhapt_PT
oaire.citation.title2nd International Conference on Human Biomonitoring, 17-19 April 2016pt_PT
oaire.fundingStream5876-PPCDTI
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsembargoedAccesspt_PT
rcaap.typeconferenceObjectpt_PT
relation.isProjectOfPublicationf42f4d14-05ea-421c-a11a-97277847498f
relation.isProjectOfPublication.latestForDiscoveryf42f4d14-05ea-421c-a11a-97277847498f

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