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eIF3: a factor for human health and disease

2017-11-03Journal article Restricted access
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dc.contributor.authorGomes-Duarte, Andreia
dc.contributor.authorLacerda, Rafaela
dc.contributor.authorMenezes, Juliane
dc.contributor.authorRomão, Luísa
dc.date.accessioned2018-03-01T17:45:15Z
dc.date.available2018-11-18T01:30:13Z
dc.date.issued2017-11-03
dc.description.abstractThe eukaryotic initiation factor 3 (eIF3) is one of the most complex translation initiation factors in mammalian cells, consisting of several subunits (eIF3a to eIF3m). It is crucial in translation initiation and termination, and in ribosomal recycling. Accordingly, deregulated eIF3 expression is associated with different pathological conditions, including cancer. In this manuscript, we discuss the interactome and function of each subunit of the human eIF3 complex. Furthermore, we review how altered levels of eIF3 subunits correlate with neurodegenerative disorders and cancer onset and development; in addition, we evaluate how such misregulation may also trigger infection cascades. A deep understanding of the molecular mechanisms underlying eIF3 role in human disease is essential to develop new eIF3-targeted therapeutic approaches and thus, overcome such conditions.pt_PT
dc.description.sponsorshipThis work was partially supported by Fundação para a Ciência e a Tecnologia (UID/MULTI/04046/2013 to BioISI from FCT/MCTES/PIDDAC and PTFC/BIM-MEC/3749/2014 to LR). JM is supported by a fellowship from Fundação para a Ciência e a Tecnologia (SFRH/BPD/98360/2013). RL is a fellow from Fundação para a Ciência e a Tecnologia through the PTDC/BIMONC/4890/2014 project.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationRNA Biol. 2018 Jan 2;15(1):26-34. doi: 10.1080/15476286.2017.1391437. Epub 2017 Nov 13pt_PT
dc.identifier.doi10.1080/15476286.2017.1391437pt_PT
dc.identifier.issn1547-6286
dc.identifier.urihttp://hdl.handle.net/10400.18/5110
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherTaylor & Francispt_PT
dc.relation.publisherversionhttps://www.tandfonline.com/doi/full/10.1080/15476286.2017.1391437pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/pt_PT
dc.subjectCancerpt_PT
dc.subjecteIF3pt_PT
dc.subjectInfectionpt_PT
dc.subjectNeurodegenerative Diseasept_PT
dc.subjectTranslationpt_PT
dc.subjectTranslation Initiation Factorpt_PT
dc.subjectTranslational Controlpt_PT
dc.subjectExpressão Génicapt_PT
dc.subjectGenómica Funcional e Estruturalpt_PT
dc.titleeIF3: a factor for human health and diseasept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FMulti%2F04046%2F2013/PT
oaire.citation.endPage34pt_PT
oaire.citation.issue1pt_PT
oaire.citation.startPage26pt_PT
oaire.citation.titleRNA Biologypt_PT
oaire.citation.volume15pt_PT
oaire.fundingStream5876
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsembargoedAccesspt_PT
rcaap.typearticlept_PT
relation.isProjectOfPublicationdc84f768-e6f2-4eea-b294-6c8ebbd1a156
relation.isProjectOfPublication.latestForDiscoverydc84f768-e6f2-4eea-b294-6c8ebbd1a156

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