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Trends of Exposure to Acrylamide as Measured by Urinary Biomarkers Levels within the HBM4EU Biomonitoring Aligned Studies (2000–2021)

2022-08-02Journal article Open access
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dc.contributor.authorPoteser, Michael
dc.contributor.authorLaguzzi, Federica
dc.contributor.authorSchettgen, Thomas
dc.contributor.authorVogel, Nina
dc.contributor.authorWeber, Till
dc.contributor.authorMurawski, Aline
dc.contributor.authorSchmidt, Phillipp
dc.contributor.authorRüther, Maria
dc.contributor.authorKolossa-Gehring, Marike
dc.contributor.authorNamorado, Sónia
dc.contributor.authorVan Nieuwenhuyse, An
dc.contributor.authorAppenzeller, Brice
dc.contributor.authorDufthaksdóttir, Edda
dc.contributor.authorOlafsdottir, Kristin
dc.contributor.authorHaug, Line Småstuen
dc.contributor.authorThomsen, Cathrine
dc.contributor.authorBarbone, Fabio
dc.contributor.authorRosolen, Valentina
dc.contributor.authorRAMBAUD, Loic
dc.contributor.authorRIOU, Margaux
dc.contributor.authorGöen, Thomas
dc.contributor.authorNübler, Stefanie
dc.contributor.authorSchäfer, Moritz
dc.contributor.authorZarrabi, Karin H.A.
dc.contributor.authorGilles, Liese
dc.contributor.authorRodriguez Martin, Laura
dc.contributor.authorSchoeters, Greta
dc.contributor.authorSepai, Ovnair
dc.contributor.authorGovarts, Eva
dc.contributor.authorMoshammer, Hanns
dc.date.accessioned2022-11-15T12:42:28Z
dc.date.available2022-11-15T12:42:28Z
dc.date.issued2022-08-02
dc.descriptionThis article belongs to the Special Issue Analysis of Human Biomonitoring Data and Risk Assessment of Human Exposure to Environmental Chemicals: What Do We Learn for Prevention?pt_PT
dc.description.abstractAcrylamide, a substance potentially carcinogenic in humans, represents a very prevalent contaminant in food and is also contained in tobacco smoke. Occupational exposure to higher concentrations of acrylamide was shown to induce neurotoxicity in humans. To minimize related risks for public health, it is vital to obtain data on the actual level of exposure in differently affected segments of the population. To achieve this aim, acrylamide has been added to the list of substances of concern to be investigated in the HBM4EU project, a European initiative to obtain biomonitoring data for a number of pollutants highly relevant for public health. This report summarizes the results obtained for acrylamide, with a focus on time-trends and recent exposure levels, obtained by HBM4EU as well as by associated studies in a total of seven European countries. Mean biomarker levels were compared by sampling year and time-trends were analyzed using linear regression models and an adequate statistical test. An increasing trend of acrylamide biomarker concentrations was found in children for the years 2014–2017, while in adults an overall increase in exposure was found to be not significant for the time period of observation (2000–2021). For smokers, represented by two studies and sampling for, over a total three years, no clear tendency was observed. In conclusion, samples from European countries indicate that average acrylamide exposure still exceeds suggested benchmark levels and may be of specific concern in children. More research is required to confirm trends of declining values observed in most recent years.pt_PT
dc.description.sponsorshipThis work received external funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No. 733032 and received co-funding from the author’s organizations. The Norwegian Institute of Public Health (NIPH) contributed to the funding of the Norwegian Environmental Biobank (NEB). The laboratory measurements were partly funded by the Research Council of Norway through research projects (275903 and 268465).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationToxics. 2022 Aug 2;10(8):443. doi: 10.3390/toxics10080443pt_PT
dc.identifier.doi10.3390/toxics10080443pt_PT
dc.identifier.issn2305-6304
dc.identifier.urihttp://hdl.handle.net/10400.18/8313
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationEuropean Human Biomonitoring Initiative
dc.relation.publisherversionhttps://www.mdpi.com/2305-6304/10/8/443pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAcrylamidept_PT
dc.subjectGlycidamidept_PT
dc.subjectExposure Levelpt_PT
dc.subjectTime-trendpt_PT
dc.subjectHBM4EUpt_PT
dc.subjectHBM4EU Aligned Studiespt_PT
dc.subjectAcrilamidapt_PT
dc.subjectCaracterização da Exposiçãopt_PT
dc.subjectVariação Temporalpt_PT
dc.subjectDeterminantes da Saúde e da Doençapt_PT
dc.titleTrends of Exposure to Acrylamide as Measured by Urinary Biomarkers Levels within the HBM4EU Biomonitoring Aligned Studies (2000–2021)pt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleEuropean Human Biomonitoring Initiative
oaire.awardURIinfo:eu-repo/grantAgreement/EC/H2020/733032/EU
oaire.citation.issue8pt_PT
oaire.citation.startPage443pt_PT
oaire.citation.titleToxicspt_PT
oaire.citation.volume10pt_PT
oaire.fundingStreamH2020
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project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.nameEuropean Commission
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