Logo do repositório
 
Publicação

Exposure to mycotoxins in the Portuguese adult population

2025-09-25Documento de conferência Acesso aberto
Ver registo simples
datacite.subject.fosCiências Naturais
datacite.subject.sdg03:Saúde de Qualidade
datacite.subject.sdg15:Proteger a Vida Terrestre
dc.contributor.authorMaris, Elias
dc.contributor.authorNamorado, Sónia
dc.contributor.authorChen, A.
dc.contributor.authorPero-Gason, Roger
dc.contributor.authorDe Boevre, Marthe
dc.contributor.authorDe Saeger, Sarah
dc.contributor.authorSilva, Maria João
dc.contributor.authorAlvito, Paula
dc.date.accessioned2026-03-04T12:25:16Z
dc.date.available2026-03-04T12:25:16Z
dc.date.issued2025-09-25
dc.descriptionAbstract disponível em: 6th International Conference on Food Contaminants: Challenges on Emerging Contaminants and Planetary Health: Book of Abstracts. http://hdl.handle.net/10400.18/10628
dc.description.abstractMycotoxins are toxic fungal metabolites commonly found in food, posing health risks such as immunosuppression, carcinogenicity, and endocrine disruption. Despite regulatory limits, chronic low-level exposure remains a concern. Understanding real-life exposure in populations is essential for effective risk assessment. This study aims to investigate mycotoxin exposure among young adults in Portugal, contributing to evidence-based public health interventions. This study leveraged data and biospecimens from the INSEF-ExpoQuim survey, a cross-sectional study nested within thPortuguese National Health Examination Survey (INSEF). Data was collected via REDCap-assisted telephone interviews, covering sociodemographic and exposure-relevant variables. A subset of 295 first morning urine samples was collected from adults aged 28–39 years between May 2019 and March 2020. Urine samples were analyzed by a newly optimized and validated LC-MS/MS method targeting 40 mycotoxins and/or their corresponding metabolites in urine. Urinary creatinine was measured using a validated colorimetric method to allow adjustment and standardization of mycotoxin concentrations, ensuring accurate exposure assessment and comparability. This methodological approach enabled a robust characterization of mycotoxin exposure in a representative Portuguese population cohort.The study included 58% females and 42% males. Most participants had medium to high education, and urbanization was nearly evenly split between towns/suburbs (36.9%) and rural areas (35.9%), with fewer living in cities (27.1%). The majority were employed, and sampling was primarily conducted in summer and autumn. The number of mycotoxin co-exposures in the Portuguese population ranged from 0 to 5, with two simultaneous exposures being most common (n = 160). Among the 40 mycotoxins analysed, deoxynivalenol and tenuazonic acid were most frequently detected, with frequency of detection of 85% and 96%, respectively. This study offers robust biomonitoring data on mycotoxin exposure in Portuguese young adults using a validated LC-MS/MS method. The high prevalence of deoxynivalenol and tenuazonic acid suggests low level dietary contamination. These findings support the need for continued monitoring and the integration ofhuman biomonitoring into national food safety strategies. Detailed sociodemographic analyses are planned to further clarify exposure patterns and enable targeted public health interventions.eng
dc.description.sponsorshipThe INSEF-ExpoQuim study is supported under the HBM4EU project that is co-funded by the European Union’s research and innovation programme Horizon 2020 under grant agreement No. 733032 and by the participating countries through the participating organizations. Thanks are also due to FCT/MCTES through national funds: CESAM UID/50017/2025 (doi.org/10.54499/UID/50017/2025) and LA/P/0094/2020 (doi.org/10.54499/LA/P/0094/2020); ToxOmics UIDB/00009/2020; and CHRC UIDP/00009/2020, UIDP/04923/2020, UIDB/04923/2020. Elias Maris is supported by an iBOF project from Flanders (grant number 01IB1320). A Chen is supported by an FWO (Research Foundation - Flanders), PhD Fellowship fundamental research (11A0725N). Roger Pero-Gascon is supported by an FWO Junior postdoctoral fellowship (12D4423N). Marthe De Boevre is supported by the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation program (grant agreement No 946192, HUMYCO)
dc.identifier.urihttp://hdl.handle.net/10400.18/11105
dc.language.isoeng
dc.peerreviewedyes
dc.relationEuropean Human Biomonitoring Initiative
dc.relationCentre for Environmental and Marine Studies
dc.relationCentre for Toxicogenomics and Human Health
dc.relationCentre for Toxicogenomics and Human Health
dc.relationComprehensive Health Research Center - Research, Education, Training and Innovation in Clinical research and Public Health
dc.relationUIDB/04923/2020
dc.relation.hasversionhttp://hdl.handle.net/10400.18/10628
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectMycotoxins
dc.subjectToxicologia
dc.subjectSegurança Alimentar
dc.subjectMicotoxinas
dc.subjectPortugal
dc.titleExposure to mycotoxins in the Portuguese adult populationeng
dc.typeconference object
dspace.entity.typePublication
oaire.awardNumber733032
oaire.awardNumberLA/P/0094/2020
oaire.awardNumberUIDB/00009/2020
oaire.awardNumberUIDP/00009/2020
oaire.awardNumberUIDP/04923/2020
oaire.awardTitleEuropean Human Biomonitoring Initiative
oaire.awardTitleCentre for Environmental and Marine Studies
oaire.awardTitleCentre for Toxicogenomics and Human Health
oaire.awardTitleCentre for Toxicogenomics and Human Health
oaire.awardTitleComprehensive Health Research Center - Research, Education, Training and Innovation in Clinical research and Public Health
oaire.awardURIinfo:eu-repo/grantAgreement/EC/H2020/733032/EU
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0094%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00009%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F00009%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F04923%2F2020/PT
oaire.citation.conferenceDate2025-09-25
oaire.citation.conferencePlaceFunchal, Madeira, Portugal
oaire.citation.title6th International Conference on Food Contaminants (ICFC): Challenges in Emerging Contaminants and Planetary Health, 25-26 september 2025
oaire.fundingStreamH2020
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameEuropean Commission
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
relation.isProjectOfPublication6815dc2d-ef7e-4535-8dd3-5193c8bffba5
relation.isProjectOfPublicationbc5e46b5-0da4-4ee2-97e0-bf2ab95a5870
relation.isProjectOfPublicationa438b9d1-8a6a-4c90-a13b-7ccf34071451
relation.isProjectOfPublication8836ec79-2300-487a-97ad-75e98cfabcfa
relation.isProjectOfPublicationfca49be7-f346-4551-94a8-e107ebc974f6
relation.isProjectOfPublication.latestForDiscovery6815dc2d-ef7e-4535-8dd3-5193c8bffba5

Ficheiros

Principais
A mostrar 1 - 2 de 2
Miniatura
Nome:
ICFC2025_resumo.pdf
Tamanho:
413.66 KB
Formato:
Adobe Portable Document Format
Ver/Abrir
Miniatura indisponível
Nome:
ICFC2025_Poster_EliasMaris.pdf
Tamanho:
1.17 MB
Formato:
Adobe Portable Document Format
Ver/Abrir
Licença
A mostrar 1 - 1 de 1
Miniatura indisponível
Nome:
license.txt
Tamanho:
4.03 KB
Formato:
Item-specific license agreed upon to submission
Descrição:
Ver/Abrir

Coleções

DAN - Posters/abstracts em congressos internacionais
DEP - Posters/abstracts em congressos internacionais
DGH - Posters/abstracts em congressos internacionais