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Micronucleus Frequencies in Lymphocytes and Reticulocytes in a Pesticide-Exposed Population in Portugal

2011-06-27Journal article Restricted access
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dc.contributor.authorCosta, C.
dc.contributor.authorSilva, S.
dc.contributor.authorNeves, J.
dc.contributor.authorCoelho, P.
dc.contributor.authorCosta, S.
dc.contributor.authorLaffon, B.
dc.contributor.authorSnawder, J.
dc.contributor.authorTeixeira, João Paulo
dc.date.accessioned2012-02-13T09:27:04Z
dc.date.available2012-02-13T09:27:04Z
dc.date.issued2011-06-27
dc.description.abstractA wide range of chemical products known to be acutely toxic is currently used in the agricultural sector, including numerous pesticides with different compositions. Nevertheless, the effects in human health as result of chronic exposure to low levels are not yet completely understood. The methodology for determination of micronuclei (MN) in lymphocytes (CBMN) is well established, and accumulating data demonstrated a correlation to enhanced risk of cancer development. However, analysis of MN in reticulocytes (MN-RET) in humans is a recent tool on human biomonitoring. The aim of this study was to examine the influence of pesticide exposure on MN-RET and CBMN frequencies. In total, 177 individuals were studied (93 controls and 84 exposed). All individuals included in the exposed group were exposed regularly to various chemicals. Both MN-RET and CBMN were significantly higher in the exposed subjects compared to controls. The CBMN frequencies were quantitatively higher in females than males, especially within the exposed group. Smoking habits exerted no marked influence on the frequency of the biomarkers studied. A significant and positive correlation was found between both indicators. Within the exposed group, data showed that there was a significant correlation between MN-RET and recent exposure (exposure in the previous 10 d) that is not found when considering CBMN. It is conceivable that due to the short life span of reticulocytes, MN-RET were found to be more reliable to characterize recent genetic damage as opposed to CBMN.por
dc.description.sponsorshipThis investigation was supported by the Portuguese Foundation for Science and Technology (FCT) under grants SFRH/BD/37190/2007 and PTDC/SAU-ESA/102367/2008.por
dc.identifier.citationJ Toxicol Environ Health A. 2011 Aug;74(15-16):960-70por
dc.identifier.issn1528-7394
dc.identifier.otherdoi: 10.1080/15287394.2011.582024
dc.identifier.urihttp://hdl.handle.net/10400.18/498
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherTaylor & Francispor
dc.relation.publisherversionhttp://www.tandfonline.com/doi/full/10.1080/15287394.2011.582024por
dc.subjectPesticidespor
dc.subjectChronic Exposurepor
dc.subjectMicronucleus Testpor
dc.subjectLymphocytespor
dc.subjectReticulocytespor
dc.subjectGenotoxicitypor
dc.subjectAr e Saúde Ocupacionalpor
dc.titleMicronucleus Frequencies in Lymphocytes and Reticulocytes in a Pesticide-Exposed Population in Portugalpor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlaceUKpor
oaire.citation.endPage970por
oaire.citation.startPage960por
oaire.citation.titleJournal of Toxicology and Environmental Health, Part A: Current Issuespor
rcaap.rightsrestrictedAccesspor
rcaap.typearticlepor

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