| Nome: | Descrição: | Tamanho: | Formato: | |
|---|---|---|---|---|
| 2.33 MB | Adobe PDF |
Orientador(es)
Resumo(s)
Background: We conducted a multicenter test-negative study to estimate vaccine effectiveness (VE) against medically attended, laboratory-confirmed influenza in primary care, Europe, 2024/25.
Research design and methods: Specimens were collected from patients with acute respiratory infection. All or a random sample of viruses were sequenced. VE was (1-odds ratio) × 100, adjusted for confounders.
Results: We included 7275 cases and 17,516 controls (weeks 40-2024-18-2025). The overall VE was 46% (95% CI: 40-52), lowest in adults ≥65 years at 28% (95% CI: 12-42). VE against influenza A(H1N1)pdm09 was 30% (95% CI: 19-40); ranging 16-34% by age and vaccination target group. Most (88%) circulating clades were 5a.2a, distinct from the vaccine clade. VE was 28% (95% CI: 7-45) against 5a.2a (C.1.9), and 6% (95% CI: -62-45) against the vaccine-matched clade 5a.2a.1 (D). VE against influenza A(H3N2) was 38% (95% CI: 26-49); ranging 20-66% by age and target group. Circulating viruses belonged to the vaccine clade 2a.3a.1, with 88% subclade (J.2). VE against influenza B was 76% (95% CI: 69-81); ranging 70-80% by age and target group; all viruses belonged to the vaccine clade V1A.3a.2, with diverse subclades.
Conclusions: Influenza vaccination protected approximately one in two vaccinated individuals against medically attended infection in primary care in Europe, 2024/25, varying by (sub)type and age.
Descrição
I-MOVE primary care network in Europe - VEBIS project: Ausenda Machado, Licínia Gomes, Daniela Dias, Camila Henriques, Nuno Verdasca (INSA).
Palavras-chave
Case Control Study Influenza Influenza Vaccine Multicenter Study Observational Study Test-Negative Design Vaccine Effectiveness VEBIS Europe Cuidados de Saúde Infecções Respiratórias
Contexto Educativo
Citação
Expert Rev Vaccines. 2026 Dec;25(1):2645378. doi: 10.1080/14760584.2026.2645378. Epub 2026 Mar 17
Editora
Taylor and Francis Group