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Fasciola Hepatica Extract Induces Cell Death of Mammalian Cells

2018-08Artigo científico Acesso restrito
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dc.contributor.authorFerreira, Stephanie
dc.contributor.authorFernandes, Ruben
dc.contributor.authorBotelho, Monica C
dc.date.accessioned2018-11-20T11:39:17Z
dc.date.available2018-11-20T11:39:17Z
dc.date.issued2018-08
dc.descriptionShort communicationpt_PT
dc.descriptionFree PMC Article: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6075840/pdf/nihms974933.pdfpt_PT
dc.description.abstractBackground: Fascioliasis is a neglected tropical disease that affects poor people from poor and developing countries. In the world, it has been estimated that at least 2.6 million people are affected with this disease. The International agency for Research on Cancer, states that O. viverrini and C. sinensis, also liver flukes, are considered as definitive causes of cholangiocarcinoma. However, fascioliasis caused by F. hepatica has not been associated with cancer to date. There are not any known causative associations between this parasite and liver cancer (cholangiocarcinoma). Methods: Chine Hamster Ovary (CHO) cells were treated with F. haepatica extracts and cell proliferation was assessed by using the indirect method for estimating cell number based on the mitochondrial activity with MTS cell proliferation reagent. We observed unexpected death of these cells when treated with F. haepatica extracts. Results and Conclusion: We now hypothesize that this parasite could be used as a medically-important trematode pathogen in cancer therapy.pt_PT
dc.description.sponsorshipThis work was financed by FEDER - Fundo Europeu de Desenvolvimento Regional funds through the COMPETE 2020 - Operacional Programme for Competitiveness and Internationalisation (POCI), Portugal 2020, and by Portuguese funds through FCT - Fundação para a Ciência e a Tecnologia/Ministério da Ciência, Tecnologia e Inovação in the framework of the project “Institute for Research and Innovation in Health Sciences” (POCI-01-0145-FEDER-007274), and by UID/BIM/04293/2013. Fernandes R. is support by SAICTPOL/24325/2016 and SAICT-POL/24358/2016.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationAntiinfect Agents. 2018;16(2):144-146. doi: 10.2174/1570180815666180531102555.pt_PT
dc.identifier.doi10.2174/1570180815666180531102555pt_PT
dc.identifier.issn1871-5214
dc.identifier.urihttp://hdl.handle.net/10400.18/5664
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherBentham Science Publisherspt_PT
dc.relation.publisherversionhttp://www.eurekaselect.com/162611/articlept_PT
dc.subjectC. sinensispt_PT
dc.subjectChine Hamster Ovary (CHO)pt_PT
dc.subjectFasciola Hepaticapt_PT
dc.subjectO. viverrinipt_PT
dc.subjectCholangiocarcinomapt_PT
dc.subjectMammalian Cellspt_PT
dc.titleFasciola Hepatica Extract Induces Cell Death of Mammalian Cellspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FBIM%2F04293%2F2013/PT
oaire.citation.endPage146pt_PT
oaire.citation.issue2pt_PT
oaire.citation.startPage144pt_PT
oaire.citation.titleAnti-Infective Agentspt_PT
oaire.citation.volume16pt_PT
oaire.fundingStream5876
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsembargoedAccesspt_PT
rcaap.typearticlept_PT
relation.isProjectOfPublicationfa9009ed-65e1-4108-bd20-1304211124ea
relation.isProjectOfPublication.latestForDiscoveryfa9009ed-65e1-4108-bd20-1304211124ea

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